folC

Putative folylpolyglutamate synthase

626 amino acids

Conversion of folates to polyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

70.637 kDa

MNKILLKRQILYNLPKYFKNNIPYTITINKSNQFINNNCKNNNNNFRKLNFTTTTTTTTTAPITNNKPKSNMLYSPKDRSYEEAVNALLTLQSNQTVIISWTKERRDNKEESAKFLMEEMRNYCKTLSIDLERESIIHVAGTKGKGSTCAITESIIREQGFSTGLFTSPHLISPRERIRINGEMISKEMFSQYFWNCWDLLIKDYQTQLPNFFRYLTLMALKIFQDEAIQCTILEVGIGGRMDSTNVFPKPMVTGISALGYDHQNLLGNTLAEIALEKAGIMKVGIPIFTVSSQLPEAINVLIDHSNKVKSPLSIVPSIDQYTISSGGGNNNNNKIESIGLKGTHQLENASLAIALANCWFKKQTFKDVNEIFNSENHKQYNYETNNYNVTQFTPLLKSIELGLKNCEWAGRAQHFTNPSHFPNMDFYLDGAHTVESSIVMLNWWKSIVNTTTTTTTTTTTTTTNNNDDDTIHILIFNSTGGRNPTSFLTPIIQSIDNKEIPIFNKSIIPNIIIEKPIDKKYYINEIIQSNQSSTATTTPIPDNAAVKQTTEIKESSTWEDFVVECYDKLSKKSHPCITADSIESSIEIAKELSENGTKNVKVLITGSLYLVGGVLKVLLKEKSFN

folC

Dihydrofolate synthase/folylpolyglutamate synthase

487 amino acids

Is involved in the bioactivation of the antituberculous drug para-aminosalicylic acid (PAS). Is able to use hydroxy-dihydropteroate (H2PtePAS) as substrate, which is the product formed by the action of DHPS (FolP1) on PAS, leading to hydroxy-dihydrofolate (H2PtePAS-Glu). This compound inhibits dihydrofolate reductase DHFR (DfrA), the next enzyme in the folate pathway, and thus disrupts the folate-dependent metabolic pathways.

Belongs to the folylpolyglutamate synthase family.

50.779 kDa

MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ

folC

Dihydrofolate synthase/folylpolyglutamate synthase

437 amino acids

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

48.826 kDa

MNNMQLKATSPLAEWLSYLEKSHFKPIDLGLDRIKSVAEKLDLLHPVPYVITVGGTNGKGTTCRLLETILLNHGLRVGVYSSPHLLRYNERVRIQNQDLPDEAHTASFAFIDENKTESLTYFEFSTLSALHLFKQAKLDVVILEVGLGGRLDATNIVDSHLAVITSIDIDHTDFLGDTREAIAFEKAGIFRENCPVVIGEPNVPQTMLDQAEKLHCQVARRDVDWLFEQNAENWQWQNKKVRLENLPFCQIPLANAATVLAAVQYLPFDISEQTLRKSLQEVELVGRFQAIKTDKREKLADYLGVPVETLPTIIVDVGHNPHAAKYLSEKLTALKRSIEGKMIAVCGMLKDKDANGVFEHLTPIIDEWHCVTLGGYRGQSGDELVEKLKSHFPNIQATSDNSVMDGVCTALKSAVKNDVVLVFGSFHTVAEFWAVVE

folC

Dihydrofolate synthase/folylpolyglutamate synthase

430 amino acids

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate, leading to folylpolyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

48.165 kDa

MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAFHVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVNQMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEPLLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHAAPFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEWLNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRFANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSWSEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK

folC

Dihydrofolate synthase/folylpolyglutamate synthase

426 amino acids

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

48.571 kDa

MINKKLARSFSLYEWLYYLDHFMLDNIDPTLNRVFYVAKKLGVLKSKAFVFIVGGTNGKGSTCHVLENLLLNSGYRVGLYTSPHLMRYTERVRINGFELEHLYHISAFNDVKYFQNDVLLTRFEFITLSALILFKSYNLDIIILEVGLGGRLDATNILSADVSVITNIDIDHSKILGVNRSSISVEKSGIFRKNKIAIVADNNFPKVAQYLAKKKKVRLRIVNIDWIYKKIEFEWSFCSSKITWLHLPLPRNVSLDSVATALSAVSESGIKINQKVFRSCISEITLCGRFETISYNPIIILDVAHNPHSARYLFKKMSSFKKNGNIFAVVGILKEKNIKDIVSPLIPIVDYWYCITLLTHRSATSSEIIKYLPNHNSQISKNMTVALEKIFDKVTNNDIVLIFGSFITVCEANKFLANKVKNFKLL

folC

Dihydrofolate synthase/folylpolyglutamate synthase

422 amino acids

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

45.406 kDa

MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGGK

folC

Dihydrofolate synthase/folylpolyglutamate synthase

418 amino acids

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

47.631 kDa

MHKKKYTFSMWMKYLEKFDKKDRKNLFELKLIAKKLGLLNLKSFFFTVGGTNGKGTTCAMLEKLLLDSGYQVGLYTSPHLINYSERIKVNGLYLSEKDHIFSFLIIDAEKGNVSLTYFEFITLSALFLFSQYSLDIIILEVGLGGRLDATNIIDSDLSVITNIGIDHTSCLGTDRISIGREKSGIFRKGKIAVIGEKNIPISVDEIAKEKKTILKKIDVDWFWTRTKIDSWNFIHSNIELYNLPVSRIPLSNTAIALASLFYSGLEVNLKKLKSSISKVQLSGRFQTVFNSPRIILDVAHNVHAALYLSEKIDEIDTEGQIYAVFGILKDKDVAGVVQVLQKKINYWYVVNLKTNRSASINYLKKKLSLNNALFFNNINESWQAIKKVITKKDIILVFGSFFTVSEFMSIKDRRLTLY

folC

Dihydrofolate synthase/folylpolyglutamate synthase

411 amino acids

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Belongs to the folylpolyglutamate synthase family.

46.97 kDa

MINKNYSLSLWLKYLEQLDKKRIYNLTELKFLAKKLGLLKSESFIFTVAGTNGKGTTCAVLERLLLDSGYQVGLYTSPHLINFVERVRINGFVLHEEEHIDSFQNVELVRNGVLLTYFEFITLAALILFKRYSLDCIILKVGLGGRLDATNIIDSDISIITNIGIDHTSILGRDRISIAREKCGVFRKNKISVIGETDIPCSMYQIAKEKKTILKKIDIDWSWEKKRNYWNFFHSTIQLYNLPETQVPLSSAATALSTLYYSRFKIKEKIIRKSISNVQLPGRFQVISTFPYIIVDVAHNPNAAFYLSQKIDEINITGKIYAVVGILKDKDILGIIDPLANKIHHWFTAPLKTIRTATKHELKKFFPIHNTSILKSIEIAYKKALILVKKEDAIIIFGSFLTVSEFLSLKI