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fcho1

Gene
fcho1
Protein
F-BAR domain only protein 1
Organism
Danio rerio
Length
897 amino acids
Function
May function in an early step of clathrin-mediated endocytosis. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
Similarity
Belongs to the FCHO family.
Mass
99.11 kDa
Sequence
MIHFFHTLQGEKNAGFDVLYHNMKHGQIATKELAEFVRERAAIEETYSKSMSKLAKMASNGSPLGTFAPMWDVFRVSSDKLALCHLELMRKMNDLIRDINKYSDEQVKIHRKTKEEAIGTLESVQSLQVQNGHLQKTREGYHSKCVELERLRKEGVPQKELEKAELKCKKAAESFAGSIEKFNRAGGDFEQKMSESAQKFQDIEEAHLRQMKLLIKGYSHSIEDTHVQVGQVHEEFKQNVENIGIENLIQKFTEQKGTGKERPEGPVGFEEYLSSLASENSKKSRAKAFRIPGLGKRDKEPDSTVHVYFLQNNSPLEVDDEGFVIRADVKQNDIEKEGNFYSSDSDFDDEEPKKFHIQIRPVASSNRSNSAANEQELKATVGALTLPPNRVVSVKKQLSRRSEGEGESVPQRVIAKVEVCACRLSSTASGSDALFGPPLESAFKSHSFSGREQLQNAFAASEFFSKFYSSSLENVEDSGLDSPSHQPLGVSPDPTGWAAWPSSQSQSKDSINAASQSRGGSNRPTPSPNPAPSSQSNTEWMNDIIREGPYSQIMQDSSERLALAPPRSVRSKRSSVAITRKNSDFSRSLCSSPLPDPNASTCVLYSKMLNCAPAGLSRGPSPISLSAQESWPVAAAITEYINAYFRGGEHNRCLVKITGDLTMSFPAGITRIFTANPNAPVLSFRLVNISRVDHFLPNQKLLYSDPSQSDPDTKDFWFNMQALTLHLQREAELNPQASYYNVALLKYQASSQDPSRAPLLLSAECQRSGTVTRVSLDYHCCPATAPATQLTSVQVLLPLDHSATDLQCQPPAAWNAEERRLLWKLDDLSSVSGSGTLCASWQCLEVPRGPAPSLAVQFVGSGASLSGLDVELVGSRYRMSLVKKRFATGKYMAGCSL

Gene
FCHO1
Protein
F-BAR domain only protein 1
Organism
Homo sapiens
Length
889 amino acids
Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
Similarity
Belongs to the FCHO family.
Mass
96.861 kDa
Sequence
MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC

Gene
Fcho1
Protein
F-BAR domain only protein 1
Organism
Mus musculus
Length
873 amino acids
Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity).
Similarity
Belongs to the FCHO family.
Mass
95.122 kDa
Sequence
MSYFGEHFWGDKNHGFEVLYHCVKQGPVATKELADFIRERANIEETYSKAMAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLHDLLKDVLRYGEEQLKTHKKCKEEVLGTVDAVQMLSGVGQLLPKSRENYLSRCMDLERLRRENTSQKEMDKAETKSKKAADSLRRSVDKYNSARADFEIKMLDSALRFQAMEEAHLQHMKALLGSYAHSVEDTHVQIGQVHEEFKQNVENVTVDMLLRKFAESKGTGREKPGPLDFDAYSSAALQEAMKRLRGAKAFRLPGLSRREPRASVDFLESDSGVPPEVDDEGFTVRPDISQNNGAEPPRFSSSDSDFDDEEPRKFYVHIKPAPTRAVACSSEAAAAQLRATAGSLILPPGPGGTMKRHSSRDTSGKPQRPRSAPRTGSCAEKPLASEEPLSKSLFGPPLESAFDHDDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPESWVPRPGTPQSPPTCRAQHPEPRGLMPRAPSPGPWGPEGGADSLTPADPTREGLAATLRRPRSRKVSCPLTRSNGDLCRSLSPSPLGSSAPTIPPDRPSFSTQMGHGISRGPSPVVLGSQDALPVATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVNTAPVEHFQPNADLIFSDPSQSDPETKDFWLNMAALTEALQHQAEQNPTASYYNLVLLRYQFSRPGPESVPLQMSAHWQCGPTLTRVSVEYSYRAGATAVSTPLTNVQILLPVGEPVTSVRLQPAATWNTEEKRFTWKLPDVCEAGGSGHLSASWQPQSGPSTPSPVAAQFTSEGATLSGLDLELLGGGYRMSLVKRRFATGMYLVSC