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fadD

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
562 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
63.479 kDa
Sequence
MEKIWFQNYPKGSEKFLDTSKYESILDMFDKAVREHPDRPAYINMGQVLTFRKLEERSRAFAAYLQNEFKLQRGDRVALMMPNLLQYPIALFGILRAGLIAVNVNPLYTPRELELQLQDSGAVAIVVVSNFASTLEKVVFNTNVKHVILTRMGDQLSFGKRTLVNFVVKYVKKLVPKYKLPHAVTFREVLSIGKYRQYVRPEISREDLAFLQYTGGTTGVAKGAMLTHGNIITNVFQAKWIAEPFIGDHSRTRSAILALPLYHVFALTVNCLLFLELGVTAILITNPRDIEGFVKELKKYRFEAITGVNTLFNALLNNENFKEVDFSALKLSVGGGMAIQQSVATRWHELTGCNIIEGYGMTECSPLIAACPINVVKHNGTIGVPVPNTDIKIIKDDGSDAKIGEAGELWVKGDQVMRGYWQRPEATSEVLKDGWMATGDIVIMDESYSLRIVDRKKDIILVSGFNVYPNEIEDVVMLNYKVSEAVAIGVPHAVSGETIKIFVVKKDDSLTRDELRNHCRQYLTGYKVPKEIEFRDELPKTNVGKILRRVLRDEEIAKRPKH

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Yersinia pestis
Length
562 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.639 kDa
Sequence
MEKVWLKRYPADVPAEIDPDRYSSLIEMFENAALRYADQPAFINMGEVMTFRKLEERSRAFAAYLQQGLGLQKGDRVALMMPNLLQYPIALFGVLRAGMIVVNVNPLYTPRELEHQLSDSGAVAIVIVSNFAHTLEKVVFKTQVRHVILTRMGDQLSAAKGTLVNFVVKYIKRLVPKYYLPDAISFRTVLQKGRRMQYVKPDVINTDTAFLQYTGGTTGVAKGAILTHRNMQSNLEQAKAAYAPLLQPGRDLVVTALPLYHIFALTVNCLLFIELGGRSLLITNPRDIPGMVKELSRYPFTAITGVNTLFNALLNNEEFTHLDFSTLRLSVGGGMPVQKAVAEKWETLTGKHLLEGYGLTECSPLVTGNPYDLKHYSGSIGLPVPSTDVRLRDDDGNDVELGKPGELWVRGPQVMLGYWQRPDATDDVLKDGWLATGDIATMDEDGFLRIVDRKKDMILVSGFNVYPNEIEEVVALHAKVLESAVIGVPNEVSGEAVKVFVVKNDASLTPEELLTHCRRYLTGYKVPKIVEFRDELPKSNVGKILRRELRDEEVKVGTTDAA

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Escherichia coli O157:H7
Length
561 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.364 kDa
Sequence
MKKVWLNRYPADVPTEINPDRYQSLVDMFEQSVARYADQPAFVNMGEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGASAIVIVSNFAHTLEKVVDKTAVQHVILTRMGDQLSTAKGTLVNFVVKYIKRLVPKYHLPDAISFRSALHNGYRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVVTALPLYHIFALTINCLLFIELGGQNLLITNPRDIPGLVKELAKYPFTAITGVNTLFNALLNNKEFQQLDFSSLHLSAGGGMPVQQVVAERWVKLTGQYLLEGYGLTECAPLVSVNPYDIDYHSGSIGLPVPSTEAKLVDDDDNEVSPGQPGELCVRGPQVMLGYWQRPDATDEIIKNGWLHTGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGEAVKIFVVKKDPSLTEESLVTFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNKA

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
561 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.332 kDa
Sequence
MKKVWLNRYPADVPTEINPDRYQSLVDMFEQSVARYADQPAFVNMGEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGASAIVIVSNFAHTLEKVVDKTAVQHVILTRMGDQLSTAKGTVVNFVVKYIKRLVPKYHLPDAISFRSALHNGYRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVVTALPLYHIFALTINCLLFIELGGQNLLITNPRDIPGLVKELAKYPFTAITGVNTLFNALLNNKEFQQLDFSSLHLSAGGGMPVQQVVAERWVKLTGQYLLEGYGLTECAPLVSVNPYDIDYHSGSIGLPVPSTEAKLVDDDDNEVPPGQPGELCVKGPQVMLGYWQRPDATDEIIKNGWLHTGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGEAVKIFVVKKDPSLTEESLVTFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNKA

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Escherichia coli (strain K12)
Length
561 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Activity is the highest with fatty acid substrates of > 10 carbon atoms (PubMed:15213221). Is involved in the aerobic beta-oxidative degradation of fatty acids, which allows aerobic growth of E.coli on fatty acids as a sole carbon and energy source (PubMed:12535077).
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.332 kDa
Sequence
MKKVWLNRYPADVPTEINPDRYQSLVDMFEQSVARYADQPAFVNMGEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGASAIVIVSNFAHTLEKVVDKTAVQHVILTRMGDQLSTAKGTVVNFVVKYIKRLVPKYHLPDAISFRSALHNGYRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVVTALPLYHIFALTINCLLFIELGGQNLLITNPRDIPGLVKELAKYPFTAITGVNTLFNALLNNKEFQQLDFSSLHLSAGGGMPVQQVVAERWVKLTGQYLLEGYGLTECAPLVSVNPYDIDYHSGSIGLPVPSTEAKLVDDDDNEVPPGQPGELCVKGPQVMLGYWQRPDATDEIIKNGWLHTGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGEAVKIFVVKKDPSLTEESLVTFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNKA

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Salmonella typhi
Length
561 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.223 kDa
Sequence
MKKVWLNRYPADVPAEINPDRYQSLVELFEHAATRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIIIVSNFAHTLEKVVEKTSVQHVILTRMGDQLSTAKGTVVNFVVKYIKRLVPKYHLPDAISFRSALQHGYRMQYVKPEVVAEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKATYGPLLHPGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSSLHLSAGGGMPVQNVVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDDDNEVAPGEAGELCVKGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDEDGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVQEVAAVGVPSGSSGEAVKLFVVKKDPALTDDALITFCRRHLTGYKVPKQVEFREELPKSNVGKILRRELRDEARGKVDNKA

Gene
fadD
Protein
Long-chain-fatty-acid--CoA ligase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
561 amino acids
Function
Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.223 kDa
Sequence
MKKVWLNRYPADVPAEINPDRYQSLVELFEHAATRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIIIVSNFAHTLEKVVEKTSVQHVILTRMGDQLSTAKGTVVNFVVKYIKRLVPKYHLPDAISFRSALQHGYRMQYVKPEVVAEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKATYGPLLHPGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSSLHLSAGGGMPVQNVVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDDDNEVAPGEAGELCVKGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDEDGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVQEVAAVGVPSGSSGEAVKLFVVKKDPALTDDALITFCRRHLTGYKVPKQVEFREELPKSNVGKILRRELRDEARGKVDNKA

Gene
Fadd
Protein
Fas-associated death domain protein
Organism
Drosophila pseudoobscura pseudoobscura
Length
241 amino acids
Function
Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (By similarity).
Mass
27.746 kDa
Sequence
MPGNHWYDILKKIACEGSSDIDELKGIFEKELSKRKFDSIRNIEDLIDVLERADMLSLHNVEPLRKMSSHKPKLIEALDRYGTPVSAPREPVNIYQEERLAEELRQHLRISQAFQILSAPGVAPPAFIPAAAPTPPPPQQNYITPAAFTDRKRTAVFNKISEELGRFWRIFGRKAGIGEGTMDDIEERYPRDLKSRILHLLKLIEEDDCHDPRQLLMRLCRALTECGRNDIKRKVEQIMSH

Gene
Fadd
Protein
Fas-associated death domain protein
Organism
Drosophila melanogaster
Length
239 amino acids
Function
Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.
Mass
27.421 kDa
Sequence
MTAGRHWSYDSLKQIAIDGCTENVEQLKLIFVEEIGSRRRSDCIRTIEDLIDCLERADELSEYNVEPLRRISGNMPQLIEALSAYTKPENILGHPVNLYQELRLAEELRQQLRIAPASQNAQPSVSELAAAVPPTAIQNYATPAAFTDHKRTMVFKKISEELGRYWRRLGRSAGIGEGQMDTIEERYPHDLKSQILRLLQLIEEDDCHDPKHFLLRLCRALGDCGRNDLRKRVEQIMSH

Gene
FADD
Protein
FAS-associated death domain protein
Organism
Bos taurus
Length
209 amino acids
Function
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).
Mass
23.002 kDa
Sequence
MDPFLVLLHSVSAGLSSSDLTQLKFLCQNHISKRKLELAQSGLDLFTVLLQQNELNAEHTALLRELLCSLRRKDLLLRLDDFERGAAGGAAPEDRDLRAAMEIICDNVGKDWRRLARHLGVSDVKIEAIEEKYPRNLAEQVRELLRVWKNSTRENAAVSCLVGALRGCQLNVVADLIEEDQRARALQSGSANPGSFTAWDSGSAAPGAS

Gene
FADD
Protein
FAS-associated death domain protein
Organism
Homo sapiens
Length
208 amino acids
Function
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Mass
23.279 kDa
Sequence
MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS

Gene
Fadd
Protein
FAS-associated death domain protein
Organism
Mus musculus
Length
205 amino acids
Function
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).
Mass
22.96 kDa
Sequence
MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP