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epsH

Gene
epsH
Protein
Putative glycosyltransferase EpsH
Organism
Bacillus subtilis (strain 168)
Length
344 amino acids
Function
May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance.
Similarity
Belongs to the glycosyltransferase 2 family.
Mass
39.809 kDa
Sequence
METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSADASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCEQMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSWNKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSIVQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSRRLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQRVIEYKMRNRG

Gene
epsH
Protein
Probable exosortase EpsH
Organism
Methylobacillus sp. (strain 12S)
Length
304 amino acids
Function
Transpeptidase that recognizes and modifies its substrate by proteolytic cleavage of a sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the exosortase and its substrate, which is then transferred and covalently attached to the cell membrane (By similarity). This sortase may recognize a tripartite structure consisting of a conserved Pro-Glu-Pro (PEP) motif, followed by a transmembrane alpha helix domain and a cluster of basic residues, usually at the C-terminus of target proteins (Probable).
Similarity
Belongs to the exosortase/archaeosortase family. Exosortase EpsH subfamily.
Mass
34.406 kDa
Sequence
MEKHIKHAIRWPSLDTIPWAWVAIAIGLLILYFPTFWDLFHGLWGTERHAHGPIVFFVSIWFFYFKFKQLPEYGITYDPSPKLGWPILVLGLLLFILGRSQTLLIFEVGSLIPVLLGITLIFMGTRVAKFLWFAFFFLCFVVPLPAFVVDAATLPMKTAVSFATAHILYALDYPIARTGVMLTIGQYQLLVADACAGLNSLFTLEVLGLLYMNVTHHESPFRNFMLAVLIIPISFIANVTRVIVLALITYHWGDAAGQGFLHEFSGIVLFITALMLVIATDSLLRFFSRKFEKVPSTQSVDLKR

Gene
epsH
Protein
Type II secretion system protein H
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
194 amino acids
Function
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
Similarity
Belongs to the GSP H family.
Mass
21.756 kDa
Sequence
MTATRGFTLLEILLVLVLVSASAVAVIATFPVSVKDEAKISAQSFYQRLLLLNEEAILSGQDFGVRIDVDTRRLTFLQLTADKGWQKWQNDKMTNQTTLKEGLQLDFELGGGAWQKDDRLFNPGSLFDEEMFADEKKEQKQEPAPQLFVLSSGEVTPFTLSIFPKGQEPDEQWRVTAQENGTLRLLAPGESDEE