elmMII

8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase

390 amino acids

O-methyltransferase involved in the biosynthesis of the permethylated L-rhamnose moiety of elloramycin, an antitumor polyketide. Mediates the methylation of the hydroxy groups at the 3'-position after the sugar moiety has been attached to the aglycon.

Belongs to the methyltransferase OleY/MycE family.

42.836 kDa

MTTPSPTPPLAAAEVAAAAGLQQRDLLAVLDRVGLEPAVAFLVHDLTARCDTPDNPDAARIGLAVEHSGHRTERVLAVRKGEPVRVDEETAGPPPVRLTFDLADLVRGVYGPPPGPGAGLFRVERDDAWFVKNADDAEPFRIFESYMRAVDVLVRAATSRPGDLGRLAARHASDKWGLWHWFTPLYEHHFARLRHQPVRVLELGIGGYQNPDEGGGSLKMWRSYFPQGRIFGVDYFPKHGLDEDRIHTLQGSQDDAGFLRRVAEEHGPFDIVIDDGSHVAGHQQTAFRTLFPAVRNGGFYVIEDLWTAYCPGYGGAATARAEGRTSIGLLKSLLDDLHYEEWTAPEPAAPGFAAPSLVGVHVYRNLAVLEKGRNSEGTIPFFAPREIDYV