Protein
Eukaryotic translation initiation factor 2A
Organism
Caenorhabditis elegans
Function
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Similarity
Belongs to the WD repeat EIF2A family.
Sequence
MGDNLVYAVRSSEGFYLKRGLGKDAVTVFEQNKTSRDVACNVFAYSNNGQLFAYCDNQVTRVFEIATNKEILCVELKRTRKILFSPKDNFLLTFEPWAVYGPKTAENQKPEPNVRVYSLADGKHVSTFSAPKEASWEPQFSDDESLAARMVGSEVFFYTNMSFDRYDHKLVEKGATNFALSPGPAPNHVAVYVPAVGSTPARVRVHRVSESFPVVGNRTFFKSDKAVMTWNQRGQSLLILASVEVDKTNQSYYGEQSLYLINIQSGESVVVPLEKKGPIYAAKWNPNGREFAVCYGYMPAKVTFYNPRGVPIFDTIEGPRNDVFYNAFGNIVLICGFGNIAKGKMEFWDVETKKEIISIEVPNTTLFDWAPDGQHFVTCTTAPRLRIDNSYRFWHYTGRMLAETHFESPKELWEVRWRPMTGYNKFAIKELTKTDKMAAGLPIRKKDASHPLNNVPAGAVRQAGAYIPPHLRKPLGGGGSAGPPSAAAPTPGNQNQRPAQPRANGNGNAPQPFRPQQSEQERKAFQLKKKVEEIKVLKQRVANGDQLQPNQMEKIQRENEYLSELSKLTI