Protein
Histone-lysine N-methyltransferase eggless
Organism
Drosophila pseudoobscura pseudoobscura
Function
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis (By similarity).
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Sequence
MASESAAMDILDSAEASLNVASTALVEKEKKVQPATDETTPEKKAKMEIDAEMKDLTNDIPNSRKSQEKDPDALEDAKDPEADSSIELLCSPTPAEATDVDAMASKTESDNSVELLESPLKSPSSNDVNDEELLPLEEKEKPGPAKELEPKESEPDSKESSKSEALADSSIELISSPTSDDSLAKEKEVEVKEEHGQQAEAQVLQEIPRKADDSFKLQDDIAMEEDVPVPRSKAMQESKETQKTSKTTTKLEPLVDSIKDAIEDCINCNCKRLKKQYVLACVAILNFYKVPRKLKRSQYVCLDCYDTAVEMYEEYAGLLLAKQPLLLREFKQEQADFVTLDSSDEEEDEKTPEKPEFSKNVLDLIENELEDAIKKTLNKVEFSNQFNWSKTILQAKIERLAKKFEEVDLQLAQVQGLADKMHCSVYNSCQVVHKQLPPLDLHQNICPSDYKRLQQLPAAGDIVRPPIKIGETYYAVKNKAIASWVSVSVMEICDTTTGGGVTVKAYKIKYQHMPYPMMKTVAAKHLAYFDPPTVRLPIGTRVIAFFDGTLVGGKEKGVVQSAFYPGIIAEPLKQNNRFRYLIFYDDGYTQYVHHSDVRLVCQASEKVWEDVHPASRDFIQKYVERYAVDRPMVQCTKGQSMNTESNGTWLYARVIEVDCSLVLMQFEADKNHTEWIYRGSLRLAPVFKETQNSLNADCAIHQMRVPRRTEPFIRYTKEMESSNMQVDQQIRAIARKSTSKSGSPASTAAPPTGSSSSSAVRHLNNSTIYVDDDTRPKGQVVHFTAKRNMPPKIFKSHKCNPGCPFPMMHRLDSYSPLSKPLLSGWERMFMKQKTKRTVVYRGPCGRNLRNMAEVHNYLRLTNNVLNVDNFDFTPDLRCLAEYYIESTIVKEADISKGQEKMAIPLVNYYDNTLPPPCEYAKQRIPTEGVNLNLDEEFLVCCDCEDDCSDKESCACWQLTVTGVRYCNPKKPIEEIGYQYKRLHEGVLTGIYECNSRCKCKKNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFVCIYAGHLLTEAKANEGGQDAGDEYFADLDYIEVAEQLKEGYESDVERADLDHEDDNYGPDAEDDDDFRPNNYYQKKKEKLRSSRSNSSSTQNTELDSQERTVISFNPNTDLDETVRENSVRRFFGKDQTPFIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVGFFASSHIRSGTELTWNYNYEVGVVPNKVLYCQCGAQNCRVRLL