eccA3

Gene

eccA3

Protein

ESX-3 secretion system protein EccA3

Organism

Mycobacterium leprae (strain TN)

Length

640 amino acids

Function

Part of an ESX-3 / type VII specialized secretion system (T7SS), which exports several proteins. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

69.057 kDa

Sequence

MLISGRSGWAILGTGGKAAVNRGDAGKLGGQSVIARAHVKVDGDVVSRFATCCRALGLAVYDRQRPADLAAARSGFTALARIAHDQCDVWIGLAAAGDVSTPVLAAISCTADTAGMLQRQVELAPAALGFHYDTGLYLQFRAIGPDDFHLAYAASLASTGGPGPYAEADQIVTGIIDRRPGWRDARWVAAVIHYRAGRWSDVVKLLTPIVNDPDIDEAYTHAAKIALGTALARLGMFAPALSYLEEPAGPVAVAAVDGALAKALVLRAHTDEESASEVLQDLYAAHPDNEQIEQALSDTSFGIVTTTAARIDARTDPWDPETEPGVEDFIDPAAHERKAVLLHEAERQLAEFIGLDEVKNQVSRLKSSVAMELVRKQRGLMVAQRAHHLVFAGPPGTGKTTIARVVAKVYCGLGLLKKENIREVHRADLIGQHIGETEAKTNAVIDSALDGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRNIDFPSYASHELVEIAHKMAEQRDSVFEQAALDELEVLFANLATSSTPDSNGISRRSLDIAGNGRFVRNIVERSEEEREFRLDHSNNVGTGELSDEELMTVTSEDVRRSVEPLLRGLGLMVPHD

Protein

ESX-3 secretion system protein EccA3: eccA3

Gene

eccA3

Protein

ESX-3 secretion system protein EccA3

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

631 amino acids

Function

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis (By similarity). EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

68.107 kDa

Sequence

MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATCCRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRTATTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKANHVVSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKITLGTALARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQLAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRNIDFPSYTSHELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVRNIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA

Protein

ESX-3 secretion system protein EccA3: eccA3

Gene

eccA3

Protein

ESX-3 secretion system protein EccA3

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

631 amino acids

Function

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis (PubMed:19684129, PubMed:24155985). EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

68.107 kDa

Sequence

Protein

ESX-3 secretion system protein EccA3: eccA3

Gene

eccA3

Protein

ESX-3 secretion system protein EccA3

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

608 amino acids

Function

Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG (PubMed:19846780, PubMed:24803520). EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

66.283 kDa

Sequence

MGSDTLAAPPHGAPRVDRDVVSRFATCCRALGLTVNDRQRPADLTAARAGFAGLTHLAHDQCDAWIGLAAAGEVTPAVVDAVWRTVASAGVLQREIGLAAGELGFTYDTGWYLQFRATEPDDFQLAYAARLYEAGEFGEADGLVGEILARRPGWFDARWLQVAINHRAQRWSDVVRLLTPVVTLPSLDDVTSHAVRTALGISLARLGMFAPAMSYLEDPAGPIEVAAVDGALAKALTLRAQGEDDEATEVLQDLFATHPENTQVEQALLDTSFGLVTTTSARIEARSDPWDPETEPSEAEFVDPGAKDRKAHLLLEAEAELAEFIGLEEVKFQVARLKSSVAMAIRRQERGLAVAQRTNHLVFAGPPGTGKTTIARVVAKIYCGLGLLKKETVREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRDRLVVIVAGYRKDLDAFLDTNEGLRSRFTRSIDFPSYTAPELVEIAVRMAEKRDSVFEKAAHDDMERLFTHLAQATTPDANGVERRSLDIAGNARFVRNLVERSEEEREYRLDHSDQEDFTDEEMMTITAGDVQRSAAPLLRGLGLSVPA

Protein

ESX-3 secretion system protein EccA3: eccA3