Protein
Zinc finger protein Dzip1
Function
Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals (PubMed:15115751). Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo (PubMed:15198976). Required for establishment of left-right asymmetry during embryogenesis (PubMed:19852954). Has a role in primary cilium formation (PubMed:19852954).
Similarity
Belongs to the DZIP C2H2-type zinc-finger protein family.
Sequence
MPFYDNVYYPYPSDPPGTHSSAGIPSLLSSPQSQPSSGSQSRPAPSTMSGPLTSSGASTSIPPPFKFRSRRENVDWRRINAVDVDRVACEMDFQALQEHINAVTFCSVEGERCHRCQSPVDPALIKLFRLAQLTVEYLLHSQDCLSISLQAAEERLLAEAREREQICVQLQKKTQDAKALKEELKQRKKIIASQQAMFSAGISANYHKCQHCEKAFMNASFLQSHMQRRHPSEFDMKLMTDNQKKIQTVKLQDEINKLQEQLTLVTSQMETQQKDYTAKQEKELIQRQEEFKRQLEIWKEEEKMRMNSKIDEVKQACQRDMDSINQRNRNLETELLKLQQKNIQESMQSVQTQPNASTSNEHWQEVVKLQQKLHKQEVKWTGKMQKMKEDHDREKSLLQEELCKVSSAVSEGMEESRRQVQELSHRLQEQQQIITSQNKQMKQISSKPPTITVQREGVSTPSPETKAKVVVSEQSNSVHKLDPIVELSEEDKDSSSISESPTENRSWQKEVQELLKNPGLRRDMRLAAQHNLDDRLQSLGIKGVSGLSKNLYKSSMTQIISDRRKKLEEDPVYRRALKEISHKLEQRVKERNTEQPVKSKLHEQVVQSRPRSSSFPSTVTRVMSGPASKQQRTPQPVPRSRTNVPHKTSTPLQHRRTPPFSSDEDSSEEEEEEEEEEESSDEESPQMQKKTVLVNSSTAKAQNTAKTQSTAQSVRSAVALTSAEPTNVTTLSDSDWTDGSEMEEINLSQLHKHTDQNGNLKNVTHSNVKALGKSLEKQLAARGPKKPAGGVNTFLEKPTDVRNTRQNAKKELKYSDDDDDDDDDWDISSLEDVPAVAKPTQCPVPVRKSLDKSQDTSTSVWGSSTGKGHKPGLTDAGTASTLKSSLVTVSDWDDSDEI