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dys2

Gene
dys2
Protein
Probable deoxyhypusine synthase 2
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
345 amino acids
Function
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Similarity
Belongs to the deoxyhypusine synthase family.
Mass
38.274 kDa
Sequence
MHHNVFTNNPTVPIDVKNRSVSELMDGMLKTGFQGRKLAESVQAWNNMLKEKNTTVFMGLSGAMVPAGMRRIISHMIRERMIDCLVSTGANLFHDCHEALGRKHYVGSHLANDEKLFEQGVDRIYDIFAVEEEFRTADNLIADFAQEIGEITCSSREFMYLLGKELGRRGAAEDSIVVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSERTGVVYVGGGVPKNFIQQTEVIASILGMDIGGHDYAIQYTSDSPHWGGLSGCTFDEAVSWGKIAPQAKKVQVFVDATIALPIVAHALHEKTHDLKRIAPVFFWDGPEGLAIDYKE

Gene
dys2
Protein
Probable deoxyhypusine synthase 2
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
345 amino acids
Function
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Similarity
Belongs to the deoxyhypusine synthase family.
Mass
38.042 kDa
Sequence
MHHNVFTNTPTIPIDVKDRSVSELMDGMLRTGFQGRKLAESVQAWSNMLKEKDTTVLMGLSGAMVPAGMRRVISYLIRERMIDCLVSTGANLFHDSHEALGRKHYVGSHLANDEKLFEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSREFMYLLGKELVRRGAAEDSIVVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSGHTGVVYVGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFDEAVSWGKVAAQAKKVQVFVDATIALPIVAHALHEKTRGVKRTAPVFSWDGPEGLEIAYNE

Gene
dys2
Protein
Probable deoxyhypusine synthase 2
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
298 amino acids
Function
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Similarity
Belongs to the deoxyhypusine synthase family.
Mass
33.015 kDa
Sequence
MARTGFQGRKLGEAFEIWTEMLREENITILMGLSGAMVPAGMRKIIAWLIRNRYIDVLVSTGANLFHDIHEAMGFRHFMGSEHVNDCKLFEEGIDRIHDVFAYEKEFNVIDYTLAEIISEMSGVMSSREFLEEIAGRLNVKDRNSIVIAAYESKVPIFSPAIADSSIGIAAALAKREVVIDTIRDVEELTEIVVNSEKTGVIYVGGGVPKNFIQQTEVVARLKGYDVRGHEYAIQITTDVPQFGGLSGCTFEEGVSWGKISGKAKKVQVNCDATIALPVLAHGLIGIRRQKYPIFNGL