Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Similarity
Belongs to the dUTPase family.
Sequence
MTADTQTPVTKVDQAPPLLIKKLSDKARLPTRGSAFAAGYDIYASKETTIPARGKGLVETDISMAVPAGTYGRIAPRSGLAAKNFIDVGAGVIDADYRGQVKVLLFNHSDVDFVVNEGDRVAQLVLERIYTPEVVEVEQLEESVRGAGGFGSTGVGSGVGEQMKN