Protein
Nonribosomal peptide synthase dtpA
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Function
Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of the dimeric diketopiperazine alkaloid ditryptophenaline (PubMed:24677498). The nonribosomal peptide synthase dtpA accepts L-tryptophan and L-phenylalanine as its substrates and forms the phenylalanyl-tryptophanyl cyclic dipeptide product cyclophenylalanyltryptophenyl (PubMed:24677498). The N-methyltransferase dtpB is responsible for the N-methylation of cyclophenylalanyltryptophenyl to yield cyclo-N-methylphenylalanyltryptophenyl (PubMed:24677498). The cytochrome P450 monooxygenase is responsible not only for pyrroloindole ring formation but also for concurrent dimerization of N-methylphenylalanyltryptophanyl diketopiperazine monomers into a homodimeric product (PubMed:24677498).
Similarity
Belongs to the NRP synthase family.
Sequence
MSCENEAPLTRSFCRTKRRDRFSHEEAARKCRIETHDIEDIRACTQEQLVYATLLSQGDEGAIAEWSFDIPESINIDFLKKAWQDMVRSKAFLRTRIIADDSPGIFLCVVMNGEPLLWTEGDGMDDPWVLGSSLARFRLIEVPNTNQRRLVVKIHHAICDPCSLYAVFESVDHAYQKKKLYNLQQNETPTACTTEGSFDDATAFPELPASVQCPSARHSLEQSVSVGTLPPSLGEITANVWLAWAITQSQYQSSDRVLFGTGSRHDEERPGFPAYVSPRLVVLDSQVAVADILQELENMFIGPAQKRTAVRTPSAEKKGMSGAVQTVVSVRRLAQHRPLTCANLVKSEKQNPFQNYALTLDCQLEKDFLIKVQAHYDHNVIPQWVTQRVLSHFMHVLPQTFHRNRDTKLASLKSLSPYDEAQLAYWNSKHVPVAEEPTHHIIHRICMEQPNAEAICSWDGKFTYNEVDVLSDSLATQLTDLGLGGSGSIIPVYMDKGRWVPIAILGVLKSGAAFTLFDPSHPLQRLKIMAEDVKAKAILCSRMTMELASQIVPQTLQIDDERGWDTIRARPGSHFSRSSRQDDALYVAFTSGSTGKPKAIVIEHGSYCTGAKEHIKAFRLSRKARVLQFALYAFDVSIMEILSTLMAGGCICILNEVQRTTPQDFEKALSSFSVTHAFLTPSFARSLRNAQLPSLDVLILGGEPMSPADAGHWASRNVVLMNAYGPAECSVNTTVQPCAAACPGNIGFTTGAACWVVDPMNHNQLVPIGGIGELLVQGPIVGRGYLNNPTLTKASFVKFVPSISAHLPGAEIIDRAYRTGDLVRQQMDGSIVYIGRKDQQVKIRGQRIELSEVEFQVQKSLEGDVDVVIEAVDIEGKSQPLLVAFLNLGIHGAQANEDLAPLAMPCEEWFRRLESMEGALKHYLPPSMIPNLFLPLVYTPTTPTGKIDRRLLRELSSRLSQAQLELYRNRNKDELKRQPYTQVEETLQRLFSQILGVEQRHISVTDSFFQLGGDSISAIRLIGAARDAGLEFTVSELLSAPTISEVALYSRALSVPKEEASPPPPFVLLGTSAKVPEILQLVANQIKLSNLDNIEDIYPCTALQEGMFALSLKSPGTYTGEVLLRLPGDVDMQRLLSAWQATVEANPILRTQIVQTPKGLFQVVMRRVDFECKQHASLDALGKLHVNQDKGVSINPMCQVALVKHNGDQHFALKIHHALCDGWSLKLILGQLDLAYRKEASLTPSYFNTFIKYLDSIAGWEDYWTSEFRDLQAPIYPALPSPSYMPRPTSLRDHAIHNLHMADSGMRLPILIKLAWSILVSNYTDSDDVVIGLTLNGRNAPVPGIEQLIGPTITTVPLRTRIHEDDTVRTASNCLHNKLTAMISYEQAGLQRIGKLNDNCRTACSFQMQVGIQPPADFNTENYCFDVLEHSIGPSMDYSDFSTYGIVVVCELSRSGTALHVKMRHDPDLVSPDEANCMVHLFEHLLRQLCENPDMRLNQLELAGPQDIKQFAKWNATAPVPVERCLHELIMNHSRTQPGASAICGWDGYVTYQELGLLITQLAYYLRTRFHIRPGMNVPICPNRSKWAIVSMLSVLYAGGSCVLLDPNHPQARMQTVISDTAADIIICNAGTEEKVTGLTRHLVIVGPELLESLPTPASLPQCLSDATPMDPAFVIFTSGSTGKPKGIIMSHKSLSTSIYYHSPQLGVNQQTRTLHFCSYAFDASIYEIFTTLVCGGCVCVPSASDCTDNLAGFITHFDVNLAIMAPSVARLLHPDSVPSLQCLVLGGEALTWEIVNLWADRVRLVNGYGPAEATIMAAGVVQASDWITGLIGPVVGANPWITKPFNPDQLVARGMIGELLIEGPVLADGYINAPEKSADPFIPAPTWLRSIRPNSAGATRLYRTGDLVQQQRDGSIRFMGRRDNQVKLRGQRIELQEVEHCVTSHVPDAVVVAEVVSFLTNERRRNELVVFIRDSTAGTEPDNITSNPEETSAIFSSPTKVDHTAMAELKAHMARNLPRYMVPWIILPLDDIPKTASGKTDRARLRVAAGKLEQKTLDQYMNIANIVKRQPSTTQEALVRSIFAQVLSLPESTIGVDDSFFNIGGDSISAMRFLTLCRQANLHLAMPAFLTYNTVALFCTNASTSIDISRFDASEEMDRNTPLVTIDHEKHISTLRTTLCNQLGLDSVLSIEDIYPCSSSHAGIIRGLAGSGDRHQVRAIFKLHGSKVVDPAHVLECWHKLIQRHAILRTVIVNNPLHPGEFLHVVLKQPPIDMASLSFQSPNVVTQLCDIHPSFDWETSPAHQMVIAQGYEGEAYCKLEAGKALIDWSSFSILVDELCLAINHLLPSKPAPLYKDFISYVQRQPLDKIMNYWERTLSGVTSSIIPRSLPEAPADPDAVPVLHSTRITLDGFKDIDAFWRGNRLTLTNIFQVAWGLVLSFHSRLPEVCFGTVVSGRDIPVTNIEDMVGPCFNILPCRLDLSPDRNIMETLQQNQQDMQRRTDHQHCSISEITRGVRQTTSTPLFNTCLSVQVSLSSQMEEPSGDLGHDIQVSMVDIHDPTEYDICLAVLIYRTQIEIDLRYWSFAFSEQDATRLLNNLRQAISHIVAHSARPIASIDWEA