dpo1

DNA polymerase 1

882 amino acids

This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.

Belongs to the DNA polymerase type-B family.

101.224 kDa

MTKQLTLFDIPSSKPAKSEQNTQQSQQSAPVEEKKVVRREWLEEAQENKIYFLLQVDYDGKKGKAVCKLFDKETQKIYALYDNTGHKPYFLVDLEPDKVGKIPKIVRDPSFDHIETVSKIDPYTWNKFKLTKIVVRDPLAVRRLRNDVPKAYEAHIKYFNNYMYDIGLIPGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEIPKIKRVAIDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKVLVLNRNDVNEGSVKLDGISVERFNTEYELLGRFFDILLEYPIVLTFNGDDFDLPYIYFRALKLGYFPEEIPIDVAGKDEAKYLAGLHIDLYKFFFNKAVRNYAFEGKYNEYNLDAVAKALLGTSKVKVDTLISFLDVEKLIEYNFRDAEITLQLTTFNNDLTMKLIVLFSRISRLGIEELTRTEISTWVKNLYYWEHRKRNWLIPLKEEILAKSSNIRTSALIKGKGYKGAVVIDPPAGIFFNITVLDFASLYPSIIRTWNLSYETVDIQQCKKPYEVKDETGEVLHIVCMDRPGITAVITGLLRDFRVKIYKKKAKNPNNSEEQKLLYDVVQRAMKVFINATYGVFGAETFPLYAPAVAESVTALGRYVITSTVKKAREEGLTVLYGDTDSLFLLNPPKNSLENIIKWVKTTFNLDLEVDKTYKFVAFSGLKKNYFGVYQDGKVDIKGMLVKKRNTPEFVKKVFNEVKELMISINSPNDVKEIKRKIVDVVKGSYEKLKNKGYNLDELAFKVMLSKPLDAYKKNTPQHVKAALQLRPFGVNVLPRDIIYYVKVRSKDGVKPVQLAKVTEIDAEKYLEALRSTFEQILRAFGVSWDEIAATMSIDSFFSYPSKGNS

dpo1

DNA polymerase 1

876 amino acids

This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.

Belongs to the DNA polymerase type-B family.

100.778 kDa

MSKQATLFDFSIKKNESKEQTNQESVEVPKQTANRTKIEWIKEAEDGKVYFLLQVDYDGKKSRAVCKLYDKEGKKIYIMQDESGHKPYFLTDIDPDKVNKITKVVRDPSFDHLELINKVDPYTGKKIRLTKIVVKDPLAVRRMRSSLPKAYEAHIKYYNNYVYDNGLIPGLIYKVNKGKLTQLNPELKGEEINEIKKAFADADEMTKETVNDWIPILETEVPDIKRVSLDIEVYTPNRGRIPDPERAEFPIISVALAGNDGSKIVLALKREDVNSDFSKKDGVQVEIFDSEKKLLARLFEIIREYPMLLTFNGDDFDIPYIYFRALRLNFSPEEVPLDVVSGEGKFLAGIHIDLYKFFFNRAVRIYAFEGKYSEYSLDAVATALLGISKVKLDTFISFLDIDKLIEYNLRDAEITLKLTTFNNNLVLKLMVLLARISKLGLEELTRTEVSTWIKNLYYWEHRKRNWLIPLKEEILVRSNQVKTAAVIKGKKYKGAVVIDPPAGVYFNVVVLDFASLYPSIIKNWNISYETIDIDECTKKVWVEDETGEKLHYVCMDKPGITAVITGLIRDFRVKVYKKKAKYSNISEEQRSLYDVVQRAMKVFINATYGVFGAENFPLYAPAVAESVTAIGRYIITTTYKQAEKLNLKVIYGDTDSLFLYNPTKDKLEELIKFVKQNFNLDLEVDKSYKYVAFSGLKKNYFGVYPDGKTEIKGMLAKKRNTPEFIKKEFAEIKNMLASLNSPNDIPEVKNKLEIKIKDIYNKLRNKGYNLDDLAFRIMLSKPLDSYTKNTPQHVKAGLQLRAFGVNVLPRDVIMFVKVKSKDGVKPIQLAKISEIDIEKYVETLRTTFEQILKAFGISWDEIVSTISIDSFFGSKK