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dphB

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
269 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
30.217 kDa
Sequence
MPLYFIGLGLYDEKDITLKGLEIAKRCDKVYAEFYTSLMAGTTLEKIEEVIGKKIIVLNREDVEMNFEKIVLPEAKEKEVAFLTAGDPMVATTHAELRIRAKRMGVESYVIHAPSIYSAVAITGLHIYKFGKSATVAYPEGNWFPTSYYDVVKENLERGLHTLLFLDIKAEKGKYMTANEAMELLLKVEEMRGENVFTPNTLVVVLGRAGSLNPTIRAGYVKDMIKEDFGKQPHVLIVPGKLHVVEAEYLVEIAGAPKEILEQFAPRKM

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Length
267 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.25 kDa
Sequence
MLDFVGLGLFDEKDISLKGLEKIHNADKVYVEFYTSILMGTDLEKMEMLYKKKITVLSREDVEQHAEDWLVDAKDSNVVFLTGGDTMVSTTHVDLRLRAADMGIKTTLIHGASIASAICGLSGLQNYRFGKSVTIPHPYVSNRGVRVVSQTPYDTIKNNIEAGLHTAVFLDIDKDKGYMTVNQAMEILLEVEGKLGEGVMVDRLAVGIARAGSPSPVVKADYIEALRDYYLGGPLHIVVIPAELHFVEAEALVKLAGAPEGILENID

Gene
dphB
Protein
Diphthine synthase
Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Length
267 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
30.168 kDa
Sequence
MLYFIGLGLSIKHLTLEAIDALRDVEKIYVDTYTNIVPDFSLDKLVSLVGEEKEFVMAKREFLEGKNIHFIVEEASKKNIAILVPGDPFIATTHDAIRVEALRRGIKVKVINGLSIYSLAPSRTGLQAYKFGKTVTLVYPEYFKPYSTIETIYDNLDRNLHTLLLLDLKIEENKAMTIPEAVDILIDLDERGVLENIIGVGLAQLGSSMEKIVADRLADLKNYTYPPPPHSIIIVAKPHPIELDNLHYVCGLPEHIYRRYSVSKTYP

Gene
dphB
Protein
Diphthine synthase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
266 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.432 kDa
Sequence
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSREDVEQQPDWLDKAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGLTGLQNYRFGKSASIPYPYESRRGAIIISETPYDTIKQNSELGLHTMIFLDIDKDKGYMTANHALELLLEVEKRRGEGIMERAVAVGIARAGSEKPVVKADYAESLKDFDFGNPLHILVVPGKLHFLEAEALVKLAAGPGKIMEETE

Gene
dphB
Protein
Diphthine synthase
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
266 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.553 kDa
Sequence
MLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSCLMGTNLEKMEKLYGKKVFLLSREDVEQHPDWLSKAKNRNLCFLTGGDTMVSTTHVDLRLRAEKLGIDTRLIHGASIASAVSGLTGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLELGLHTLVFLDIDKEKGYMTVNTALELLLEVEEKRGEGIMRGAAAVGIARAGSEKPVIRADYAENLKDFNFGKPLHILVIPGKLHFLEAEALVKLAGGPVGFMKEVE

Gene
dphB
Protein
Diphthine synthase
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
266 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.397 kDa
Sequence
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSREDVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGLTGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSVNIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVPGKLHFLEAEALVKLADGPEEIMENIE

Gene
dphB
Protein
Diphthine synthase
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara)
Length
266 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.033 kDa
Sequence
MLTFVGLGLYDERSITVAGREALRSADRVFAEFYTSKLAGATVEELQNHHDIDIEVRDRAGVEQEPGPILDAAEAGGAVFLTAGDTMISTTHVDLRLRADNRGIETQIIHGTTAGAAAASLSGLQNYRFGKATTLPFPYAHGGEGVPGSVLDTIADNRKRGLHTLVYLDIKVGTGPRGPDPDHEEYMTADYAAELLAEDLDTVGVAIARAGSPDPVLAADRLSALADRSFGDPLHLLIVPGDLHVVEHDALVALAGAPESALPDPV

Gene
dphB
Protein
Diphthine synthase
Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)
Length
265 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.441 kDa
Sequence
MLFFVGLGLYDERDISVKGLEIVRCADAVYAEFYTSRLMGTSIERLEQLYGREIRMLSRSEIEGEPEWLEHARDRNVALLVGGDPMISTTHLDLRLRAIEMGIDTRVIHGSNIASAVPGITGLQNYRFGRSATVPFPHIVRGKRIVSSTPYNAVKDNLRRDLHTLLYLDIQDERFMCINEAAALLIEVANGSGDEDFASNLAVGIARAGSEDMCVRAGTLLELKTYSFGPPLHVMVIPGRLHFMEAKALRMLAGAPEELLSGYEL

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
265 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.576 kDa
Sequence
MVLYFIGLGLYDERDITVKGLEIAKKCDYVFAEFYTSLMAGTTLGRIQKLIGKEIRVLSREDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIRAKRAGVESYVIHAPSIYSAVGITGLHIYKFGKSATVAYPEGNWFPTSYYDVIKENAERGLHTLLFLDIKAEKRMYMTANEAMELLLKVEDMKKGGVFTDDTLVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPGKLHIVEAEYLVEIAGAPREILRVNV

Gene
dphB
Protein
Diphthine synthase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
264 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.858 kDa
Sequence
MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRSVKVLGRGEIEEERIPIERALELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGLAGLQAYKFGRIITIPFTSDNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTATEGLRYLLKASEKLDDGTISGETLAVVIARAGSEKPLVRADKIATLVEEDFGDPLHCLVVPAGLHFIEADYLVEIAGAPRAVVERMIL

Gene
dphB
Protein
Diphthine synthase
Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Length
264 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.757 kDa
Sequence
MALYFIGLGLYDERDITLKGLKTARKCDKIFAEFYTSLLAGTTMERIEGLIGKPIIRLSREDVELNFEKIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAVAVTGLQIYKFGKSATVAYPERNWFPTSYYDVIKENRERGLHTLLFLDIKAEQNRYMTANEAMEILLQVEDMKKEGIFTPETLVVVLARAGSLNPTIRAGYVKDMIHEDFGRQPHVLIVPGRLHVVEAEYLVEFAGAPEEILEEV

Gene
dphB
Protein
Diphthine synthase
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
264 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.687 kDa
Sequence
MVLYFIGLGLYDEKDITLKGLETARRCDKVFAEFYTSLLAGTTLEKIEELIGKPIVRLSREDVELNFERIVLPEAKDKDVAFLTAGDPMVATTHSDLRIRAKKAGVKSYVIHAPSIYSAVAITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRDNKERGLHTLLFLDIKADQNRYMTANEAMEILLKVEEMKGEGVFTPETLVVVLARAGSLEPTLRAGYVRELINEDFGRQPHVLIVPGRLHIVEAEYLVEFAGAPEKILEEV

Gene
dphB
Protein
Diphthine synthase
Organism
Thermococcus onnurineus (strain NA1)
Length
264 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.663 kDa
Sequence
MAIYFIGLGLYDEKDITLKGLETARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSREEVELQFERIVLSEAKGKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAIAITGLQVYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQNRYMTANEAMEILLQVEEMKGEGVFTPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGRQPHVMVVPGRLHIVEAEYLVTFAGAPRKILDEV

Gene
dphB
Protein
Diphthine synthase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
263 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.155 kDa
Sequence
MGELYLVGGGLSDVRDLTLRALEVLASVELVLVDTYTSVYDVSEGDLKRLLNGFGGDPEVRMCSRRDLEERFFDLCEGYDRVALLSPGDPMAATTHVALVVEAADRGWDVEIINGVSVFTAAPSKSGLEMYRFGRTATIPLNVRSVYPYDVLESNRQAGLHTLFLLEVAEDGEFVSVADAARYLLEIEREEGRGVLDPSDLAIAVVRLGFEDELVAWGTLEELSDWEPGEPPQALILPASRLREAEREYIRRVLPHIRDVRGV

Gene
dphB
Protein
Diphthine synthase
Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Length
263 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.249 kDa
Sequence
MLYFIGLGLFSEDDISYKGFKALKSVDCIYAEFYTAKLMGGNIDNLIEKLDVPFITLKREDVEDANVIIKEAMTKDIAFVTAGDSLMATTHTELYVEAINKGIKTQIIHGSSIFSAAPGISGLQAYKFGKTTTVPFPDENFFPHSPYDAIKLNSQMGLHTLVLLDIQAHKDRYMTVNQALDYLSKVESERKEHVFDDDRIVIGIAQAGSKHPIVKGGRVSDVKNFDFGKPLHCIIVPANLHFIEAEALITLADVDKELLKDFL

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
262 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.593 kDa
Sequence
MALYFIGLGLYDEKDITLKGLEIARKCDYVFAEFYTSLMAGTNLERIEKLIGKEIRVLSREDVELNFERIVLPLAKDHDVAFLTAGDPLVATTHAELRLRAKKFGVESYVIHAPSIYSAIAITGLHIYKFGKSATISYPEKNWFPTSYYDVIKENLERGLHTLLFLDIKAEKGKYMTANEGMKLLLKVEDMKKEGVFTQETLVVVLARAGSLNPVIRAGYVRDMIREDFGSPPHVLIVPGRLHIVEAEYLVEIAGAPREIIR

Gene
dphB
Protein
Diphthine synthase
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
260 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.346 kDa
Sequence
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRAGVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAGLTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGDAYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGSLHHIERDALRELAGAPADAL

Gene
dphB
Protein
Diphthine synthase
Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Length
260 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.086 kDa
Sequence
MLTFIGLGLYDERSISIAGRDALQAADYVAAEFYTSYLVDATVSDLETAHDIDIDVRDREGVEQHPEDILRKAQSEDVAFLTAGDTMISTTHTDLRLRAIDRGIDTRVIHGVTAQTAASGLTGLQNYRFGKSVTLPFPYAHGAEGVPTSVTDSIAANRERGLHTVVYLDIKANRDEYLRASDAAEMLATDLEDMLAIAVARAGSPDPTVRADRLSALAEKDFGDPLHLLVLPGELHHLEEEALAALADAPADMLNAVDSQ

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.91 kDa
Sequence
MIILAGLGLYDEKDTTLKTVEFAKKADKIYAEFYTAILTGTTIEKIEETLGKEITILDREKVELETEKLINESKDKDIMFLTAGDPMVATTHIDIAIEAKKKGIEVIILNAPSIYSAIGITGLQLYKFGKTTSIVFPEPNYFPETPYDVIKENSKMGYHTLCLLDIQAHNTRFMTANEGLEVLLKIEEKRNENILNKDTKVVVVARAGSLKPKMVYGKIGDLLEYDFGAPLHCIIFTGNLHFMEEDALKYLCENISE

Gene
dphB
Protein
Diphthine synthase
Organism
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.332 kDa
Sequence
MLTFIGLGLYDQKDISVKGLEAIREADVVYAEFYTSRLMGATLEDMQELYGKPVKVLMREDVEQHPKDTVLSDAVDKKVVFLTGGDAMVATTHVDLRLRAKKMGIETRLIHGASIQSAVCGLTGLQNYRFGKSATIAFPYKDIISETPYDTILMNKKNGLHTLLFLDIDREKGYMTVNRGIELLLKVEERRKEGAVAGALCVGIARAGSPSPCVRAGRIEELQAFDFGGPLHIMVMPADLHFLEEEALQDLAGLKLG

Gene
dphB
Protein
Diphthine synthase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.037 kDa
Sequence
MLILAGLGLYDENDMTLKTLKFAKKAEKIYAEFYTAVLTGTTTEKIEEVLGKKIHVLSRKDVEYNGYKLIEEAKDKDIMFLTAGDPMVATTHVDLAIEAKKKGIEVLIINAPSIYSAVGITGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIDENEKRFMTANEGLKVLLELENRKKEGIINEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIPGKLHFMEEDALKYLCENI

Gene
dphB
Protein
Diphthine synthase
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.834 kDa
Sequence
MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEADRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTANEALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIPGNLHYMEADAIKWILRS

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfolobus islandicus (strain M.16.27)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.757 kDa
Sequence
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.757 kDa
Sequence
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.757 kDa
Sequence
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.757 kDa
Sequence
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.757 kDa
Sequence
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.757 kDa
Sequence
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS

Gene
dphB
Protein
Diphthine synthase
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Length
257 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.767 kDa
Sequence
MLNIIGVGLRGTGSITFDEFDALRTSDFVYADMYTSIGQPGLIRKISAMIDRDILPLTRDEIENGSILPQAASKNVSLIVVGDPLMATTHNELRYEAMNQGIGVRIFENASILNAAIGKAGLMVYKVAPPVSLPRISEKFFPLSVIDKIKRNADLGLHTPVLIDLEDQENIPLHDALASLLEMERRREYSGIIREICVLSRISFPDEKILFGRIEDMMQQEVNSPYMMFILSKLDDNERRFLSLFSESVSKVSDARS

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.655 kDa
Sequence
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKVEETLQKPITVLDREKVEYETNKLIEEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGITGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGLSALLEIEEKRNENVISGETHAAVVARAGSTKPGLYYGKIKDLINYDFGTPLHCVIIPGKLHFMEEDALKYLFENI

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.793 kDa
Sequence
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKVEETLQKPITVLNREKVEYETNKLIEEAKNKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGITGLQLYKFGKTTSVVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGLDTLLKIEEKRNEKVISGETYAAVVARAGSTKPGLYYGKIKDLINYDFKSPLHCVIIPGKLHFMEEDALKYLFENI

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.662 kDa
Sequence
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTSMEKIENTLQKPITVLDREKVEYETNKLIEEAVDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGITGLQLYKFGKTTSVVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGLDALLKIEEKRNENVISGETYAAVVARAGSIKPGLYYGKIKDLINYDFGTPLHCVIIPGKLHFMEEDALKYLFENI

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcus maripaludis (strain S2 / LL)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.771 kDa
Sequence
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDREKVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGITGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGLDALLKIEEKRKENVISEETEVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKLHFMEEDALKYLFENI

Gene
dphB
Protein
Diphthine synthase
Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.815 kDa
Sequence
MLVMAGLGLYDELDVTLKTVEFAKKVDKIYAEFYTAILTGTTIEKIEKTLQKEITVLNREKVEYETNKLIEEAKEKDIMFLTAGDPMVATTHVDIAVEARKKGIEVIILNAPSIYSAIGITGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLSLGYHTLCLLDIQTDKQKFMTANEGLSVLLEIEEKRKEKIIDENTKVLVVARAGSIKPGLFYGKIKDLIKHDFGTPLHCVIILGKLHFMETDALKYLFENI

Gene
dphB
Protein
Diphthine synthase
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Length
254 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
28.135 kDa
Sequence
MADIYFVGLGLSKRFLTNASLEVLKGSDVIYADIYTSISCDINEKTLREITGKEIIPATREVLETKEKEIYKLLDSGKNVAIAVVGDPMIATTHVSLATGARARGHRVSVIPGVSVHCYMISRSMLSSYKFGKSVTVTFPVLDKLDYTPYRVIKTNRELGLHTMVYLDLKETGIMTADLALNYLKKMESDIGDKVILDDDLVVIGERLGCADERVRAMKVVDALNQKFGAPPHIIIVPSRNLYEMEVEGLKCLS

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
254 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.572 kDa
Sequence
MLSLVGLGPGRGYVTEAAAEAIKNADCVFYEDYTAPLDVEALRRLARGEPIRLTRADLEDHSGRKIFECLKEGKRAVLVTGGDPMLATAHAAILALARRRGYRVEVVPGVSIICAAFSLSCLSIYKLGGVATVTYPRGGVYSTRPYDLVEQNLQRGLHTLLLLDVREDGRFMPPREGAEVLLQLEERVGRGLFKEDLPIVVVYKVGWGGSAVYATLGEIARSDLEGPAVFIVPSRLGPVEKECLEGLSARSSTR

Gene
dphB
Protein
Diphthine synthase
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
254 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
29.136 kDa
Sequence
MPTLKLIGLGLSAKFVTREAIDEISKCNVVLFESYTSLSCDINLDFIKFLNKNVIIVDRKFIENNIKEIIKLLKEKEDVCIVTIGDPMIATTHVSLIVEVKDKGYNFKVIPGISVHCYIISKSMLSSYKFGKSVTITYPYNNKIDTTPYDVIYDNFIRGLHTILYLDLKEDKIMTAKEAVELLIEMEKIKKQGLVSDDRIIIVGQRLGCDDEEVVALRLKEVFNYKFKEPPHIIVFPTDKLHFMEVEALKCLMK

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta)
Length
253 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.45 kDa
Sequence
MFYIIGVGPAPGFITEKAAQILREADCVFYEDYTGPIDVETLRRYARSPPTRLTRRDLEDESGRRVLECLSRGKTAVLATAGDPMLATSHAALISIARSRGYSVEVVPGVSIVCAAFSASCLSIYKLGGVATVTYPRGGVYSARPYELVEQNLARGLHTLLLLDVREDGVFMPPRDAAEIMLKLEEREKRGVFDKGRPVVVVPKLGWGGRPAYLPLGELLGSDLEGPAVFIVPGGLSPVERECIEALSVLKSR

Gene
dphB
Protein
Diphthine synthase
Organism
Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
Length
252 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.658 kDa
Sequence
MLIFVGLGLYDLDDISLKGLQAIKEADAVFLETYTSVLTGTTIEQMREKYGKDLIILKRQDVEQKPEPILTAAKNGIAVFLTGGDPMVSTTHADLRIRAHEQGIPTKIIHGSSIVSAVSGLTGLQNYRFGKSCSIPYPAPKWFPKTPLDTILANLKQNLHTIVYLDIQENRYMSVHEGIELLEKLMEGSTDSIPLFVGIARAGSNSPVVAAGSSERLKLVDFGPPLHILVVPASLHEIEEEYLKNFAGYDPQ

Gene
dphB
Protein
Diphthine synthase
Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Length
252 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.852 kDa
Sequence
MLTFIGLGLFDEYDVSVRGLDAIKSADTVFLEVYTSVLMGAPIERLEAFYGKKITPLYREDVEIHADKILDAAEFGNAVFLTAGDSMVATTHSDLRIRAADRNIPTTIIHGASITTAVCGLSGLQNYRFGKSVSVPFPYGKWFPMTPIEVISANLKENLHTLVFLDIQKDKERYMKISEAVDLLEEQARRVDAGIPLYVGIARAGSPEPTVHAGNAEEMKAFDFGSPLHILIVPATLHEIEREYLERFAGLC

Gene
dphB
Protein
Diphthine synthase
Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Length
251 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
26.977 kDa
Sequence
MLTFVGLGLYDAGDISVKGLEAVRASDAVFLEYYTSRLMGTTIEDLVRAYGKEVIVLARADVEQHPEPILDAAAAGDVVVLTGGDPMVSTTHMDLRLRAAARGIPTGIIHGASIQTAVCGLTGLQNYRFGKSCSVPFPQKNWFPLTPYEVVRQNLAADLHTLVYLDIQQDRYMRVGEAIDLLEEMAVRVGGSITTYIGVARAGSVSPVVRAGTADHLRGIDFGGPLHVLIVPATLHPVEQEYLEVFAGLSV

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Length
251 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
26.829 kDa
Sequence
MLYIVGIGPGPGYATERAIRAIEEADCVFYEDYTGPIDVETLRRAAKTPPIRLTRRDLEDESGRKVLECLREGKRAVLATAGDPMLATAHAALIAAARARGHPVEVVPGVSIICAAFSAACLSIYKLGGVATVTYPRGGVYSTRPYELAEANLARGLHTLLLLDVREDGSFMPPRDAAEVLMALEERERRGVFTPQRPAVVVHRLGWGGGVVVGPLGAVAKWDGEGPAVLIIPAQLGPVEKECLEAVAQRI

Gene
dphB
Protein
Diphthine synthase
Organism
Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Length
250 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.454 kDa
Sequence
MLTFIGLGLYDKTDVSEKGLAMIRSADYVFLEGYTSRLMGTNITELEAFYKKPVRLLLRADVEQHPDELLDCAARGNTVFLCAGDPMVSTTHADLRIRAAERGIPTAIIHGSSIVSAVCGLSGLQNYRFGKSCSVPFPQGNWAPSSPLDVILENRTNRLHTLVYLDIQDDRYMTVNEGICLLEAMAQKKQVAIPFYVGVARAGSETSLVRAGTAETLRSADFGPPLHILIVPGELHDMEREYLARFAGLC

Gene
dphB
Protein
Diphthine synthase
Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Length
250 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
26.944 kDa
Sequence
MLTFVGLGLYDLGDISVKGLEYVRNADTVFLEAYTSRLMGTDTAAMEAFFEKDIRVLGREDVEQTPREILECAAAGRVAFLTGGDPMVSTTHADLRMRAAAAGIETSIIHASSISSAVSGLSGLQNYRFGRSCSVPFPAKGWFPTAPIETIAANLALNLHTLVFLDIQNDRYMRVPEAIAVLEEMAEKRGIEPPALYVGIARAGSERPVVAAGAGANLKEMDFGPPLHILAVPADLHPMEREYLETFAGL

Gene
dphB
Protein
Diphthine synthase
Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Length
249 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
27.2 kDa
Sequence
MFYIVGIGPGPGYITERAIQILQEVECIFYEDYTGPLDVATLRRYARVEPVKLARRDLEDESGRKIFECLQEGKKAALVTAGDPMLATSHAALITLAKAKGYSVEVVPGVSIICAAFSASCLSIYKLGGVATVTYPRGGVYSVRPYELVEQNLARGLHTLLLLDIRDDGVFMSPRDAAEVLLTLEGRERRGVFTRDRRVVVVSKLGWGGSVLYAPLGEIVQSEMEGPAVFIVPAGLNPVERECIKTFSK

Gene
dphB
Protein
Diphthine synthase
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Length
206 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
22.828 kDa
Sequence
MLNIIGIGLRGTGSLTLDEFDALRTSDIVYLDIYTSIGPKDILEKLRNIADREIIPADRNMIESESILKDAEKLNVSLLVIGDGLTATTHNQLRYSAMEKGIKVKIFENASAVNTAAGKIGLLHYKVGPPVSLPFVSSNFFPLSVIDKVKRNYDSGLHTPILIDLKDGQNMPFASAWNIIMEMQKRKGVCNNRRKCMRCLEAFISG