dph-2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

602 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

65.335 kDa

MAGELNAAPVLSTPEDHLFEYAVVPTDDQTKAKSDDELRDIYEITRTAKEVGEGGWRRIGLQFPDHMLCDAPRVVQLLEAELASLPQPTVPTSTADLQSTATACPEPSTTNNGQCGRNVQQNGTGCGCGKQAPAPVESQPKARRVYVLADTSYSACCVDEIAAEHVNADVVVHYGRSCLSPTSRLPVIYVFTKHILDRDAALVKFEKEYPDKEAKVVLMADVTYQVHVPSLLSELQSGGYVNLLATEIVHNPMGRIPNRKVVDAQGKEVEISHGSETSTGLDLRDYSIFHISQPPTALLLALCSRVKNLYIFQTSSDSSSLYSAQRLLGRRYARLLSLTTAGIIGILVNTLSVSNYLSSIDSIRKQIAAAGKKSYTMVVGKLNPAKLANFAEIDGWVVVGCWESSLIEDDAGFYKPVITPFELELALASDDERVWTGEWWGGIEAVKPPIDEKPGEKKSEENENNEAQDTAGAEQASGDGELDSEEESAPPEFDWRTGKLVSHSRPMRMAASKPKSAKKEDSSDKPDAPPRSSALTLRSKAQELASVNGVVSPGAEYLRTQRTWVGLGTDFDEEASMTIEEGRGGVARGYTVGGEGEKHLMS

dph-2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

476 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.955 kDa

MTESAPSAFFTTSTPADHVHEEESSNTGYFENLPENDIHSFFEIDATSEWIKQGNHQRIALQFPDSLLPYSEKVTKLIESRFRSESAKKTFVLADTSYRSCCVDEVAAAHADCTALVHFGEACHSAPTDKIDVKYVLGSMPIFIDQFRMEFQNVADQLTAEHIVLLMDSCFSHEQEKVAAVIKEVLPGNRHVECSLLPSEDVLKQNRQNIYLGREIPSCLRNNQPTDLIFCGFPNSPLLPIWLLSYPSCSTVSHFNPINKTIQHESTRSSRLLRKRLFLVEKLKDADTVGLVVGSVGVDKHREAVKRMREMCKKAGKKIYVISVGKINVPKLSNFSTDIDVFVLLSCPFGVVLDSSDYFRPVVSYFEAEIALNPAKTWAADFGWSAEFAAFLEDKIETEVPDDKAAGDFSLISGKVRVQKTEEEKNGDGPSSVAIYNPGYCNDRTWKGLNDGVSTAEDSTKMGEGRSGIAQGYSGK