Protein
Anthracycline biosynthesis protein DnrQ
Organism
Streptomyces peucetius
Function
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. DnrQ is required for the glycosylation of epsilon-rhodomycinone by DnrS to yield rhodomycin D.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MPTPTSAPPAAPTDSELGRHLLTVRGFHFVFGALGDPYARRLRGEADHLSLGELVRDRGPLHGSALGTWVTADGGISARLLDDPLLGPRHPASEGPQEHVLENVWETWRTCHVTPLGEDLLTPAAADSDRLAALLGPVLGPRTCTAWQVDAGRAVHRVLDGLPPHFDVVSDLARPAIAGSLAAVLGLPDEARAELPDLLAACGPVLDSALCPPRLPVARAMTQALRRVRELMAAAVANHLTAPADGAVSALLAVDPGGGRDPGDTVTAAVLSTVVGAETAITTVANAVMALLKHDEQWSLLRADPGRAADAVEETLRWAPPVTLRSLITQGEVQIGGETLEADQHVVVLVDAAQRDPALYEDPDRFRLDRPRSPGFTHMALAGRDHLGLVAPLVRVQCTAVLRALAERLPGLRAEGEPLRRGRSPVVRAPLSLRLAQK