dlk-1

Gene

dlk-1

Protein

Mitogen-activated protein kinase kinase kinase dlk-1

Organism

Caenorhabditis elegans

Length

928 amino acids

Function

Isoform c: By forming heterooligomers with isoform a, acts as an inhibitor of isoform a activation. Its inhibitory function is independent of its catalytic activity.

Similarity

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Mass

103.483 kDa

Sequence

MTSTTMVTTLDLVTPTSEEQPGPAPESSDFSTVVLSPDGSELVTQSAPNTPIQHREQANAEFGQKEGSPDPKNMVAATGNASKPSLNSFYADGLGQLRNGLFSCFQPVFGYFGTKTTVEIEKSEDELWEIPFDAISELEWLGSGSQGAVFRGQLENRTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHWEIFKPELFEMTEEEWQLAWDSYREFAKCIQYPSTVTRDHGGPKSAFAMEEEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGCFTELKLKESELAEWEKDLTEREQWHNQNSPKAVAAPRAQLRGYPNEGYDDMSSDEDVQPCRGSPYRCSNTSSSSGVQSSPFSRQSSSRSSAGQQTRRSEGANPPKILRNDAIRHSGSYWETLGGARGSPARDSGFSQDSGMWSAGAGSCTAINGGGQQVCYSQTLYRNGDGRWSDGRIASRRRVSTSVNKSTAVPGQPVFFTRDSPSRVPHGVISCSSPRSSSKLNRSSYPSRNAPHQLEDGCCCAHARAPRAKSIAVPMTSSSRARSPTPYDNDFENAESFVDPESPKNLKNLEKIVNLPESTSYDEALCNSDVTMNPIYTSPITTYSNPCHVELVDEENANDVDLTSSMDSRRSRSDDADVESSEEDEGNGNNILNTSMESEDLRYRIDTSQSTMMSSLERSLEIGATRSDGLSDNEMRVQAVKMSIKTHRRTGSNPQALIHQCIDEYTTSATDDSDDAGAVRI

Protein

Mitogen-activated protein kinase kinase kinase dlk-1: dlk-1

Gene

dlk-1

Protein

Mitogen-activated protein kinase kinase kinase dlk-1

Organism

Caenorhabditis elegans

Length

928 amino acids

Function

Isoform c: By forming heterooligomers with isoform a, acts as an inhibitor of isoform a activation. Its inhibitory function is independent of its catalytic activity.

Similarity

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Mass

103.483 kDa

Sequence

Protein

Mitogen-activated protein kinase kinase kinase dlk-1: dlk-1

Gene

dlk-1

Protein

Mitogen-activated protein kinase kinase kinase dlk-1

Organism

Caenorhabditis briggsae

Length

857 amino acids

Function

Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4 (By similarity).

Similarity

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Mass

96.346 kDa

Sequence

MMAAAGNASKPSLNNFYAEGLGHLREGLFSCFRPVLGYFGGKPTQEIEKTEDEGWEIPFDAISNLEWLGSGSQGAVFHGQYENRTVAVKKVNQLKETEIKHLRHLRHKNIIEFLGVCSKSPCYCIVMEYCPKGQLCTVLRQKNLITRQMFSDWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHLQKKNDSTMMSFCGTVSWMAPEMIKKEPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILNLPMPEEAPRGLVLLIKQCLSQKGRNRPSFSHIRQHWEIFKPELFEMTEDEWQVAWDSYREFAKAIQYPSTVTKDHGGPKSAFAMEEEMQRKRHEQLNHIKDIRHMYEAKLKRTNKMYDKLQGCFTELKLKEHELAEWERNLAEREQMHVYNSPRSMSAAPRFQLRGNCYPNEAYEEMSSDEDGQCPPCRGSPYRNSNMSTSSGAQSSPFSRQSSCRSSAGQQTRRSEGANAQKISRNDLLRHSSSYWETIGNRGSPARGSGFSQDSGVWSAGVSSMAINGGVQGGVPVTYAQTIYRNGEGRWSDGRIASRRRVSSSANKNLPPVFFTRDSPSRVPHGVVNHSAPRSSSKLNRSSYPSRNAPHQLEDGCCCNHGRVPRAKSVAVSMATRGRSPTPYDNDASDAAENPDIHYELQIPETTSYDEALKSIGETDDVEMDAANGVNPIYSSPITTYNNPCHVNYENVTEENANDIDLTSSMDSRRSRADDADVESSEDEGNGNNILNTSMESEELRYRIDTSQSTMMSSLERSLEIGATRSDGLSDNERRVQAVKHSIKTHRRTSSNPQAIIHQRIEEYSSSATEDSDDAGAVRI

Protein

Mitogen-activated protein kinase kinase kinase dlk-1: dlk-1

Gene

dlk-1

Protein

Mitogen-activated protein kinase kinase kinase dlk-1

Organism

Caenorhabditis briggsae

Length

857 amino acids

Function

Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4 (By similarity).

Similarity

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Mass

96.346 kDa

Sequence

Protein

Mitogen-activated protein kinase kinase kinase dlk-1: dlk-1