Protein
DNA polymerase IV 1
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Function
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity).
Similarity
Belongs to the DNA polymerase type-Y family.
Sequence
MGKGRVIFHVDMNSFYASVEMAYDPSLKGKAIAVAGSVKDRRGIVVTSSYEARAKGVRSPIPVWQALRKCPELILIPPNFDRYRSASQKIFSLLEEYTPLVEKVSIDEGYMDVTTTIKKVHPLELAKEIQQRILAEMDLPCSIGIAPNKFLAKMASDMKKPLGITVLRKRDIAEKLWSLPIEEMYGIGRRSVDTYKKYQLHTIGDLAKADPAWLEKKFGINGPRLHCRANGIDERPVDPEAVFHFKSVGNSTTLPEDTTNEGRLTDVLHQLSHSVHVRMKRKHVFCYGVQLTIRYDDRKTITRSRKLEHPIQEKDDIFTVALSLWKQAWNGRPIRLLGVTGYDVIDKKYAYEPLDLFRYEEQIKQATLAETISSIHKRYGKPIVAKGKDLDLFKEVDETKKGTSFDRDFFQHD