Protein
Hybrid signal transduction histidine kinase C
Organism
Dictyostelium discoideum
Function
Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.
Sequence
MIVEVELGFLLSTLFFTIISIILFYFFINNKNNLIDQCQEVTKLNNKDNKIVNNNNNNYNNNNFNKIEEINDDKNKEIIKLINNSNNKNLKIKIQEIDSGNNNNNNNNNNNNNNNNLNKNSNEIFRNFKIFSGSLLVIDQDLNIISSSESVRDIFSNINDINGVNQQVIGSLQNYSFINLVHQKDKDRVSTFLKLKFKNNNNIKHQQFSEDIINEKDELKEIQIEDNKELIIINNNNNNNNDNVLKFGNNNSNNSSIILFQGVYHLNNTDLSKPFNLQVSILPFISENYIVLSLKDLSPPPLRLLLNKTSSALSPRSLSSSSSSSPSSSNNNGNTNNSGSLSPRSSNSNGSAVSPRNVSSNSMSPRGQNSDRSISSPRGSSSSSSSSSNELAISPRNSNGTISSPRTSNLSIESVLNNKSIDMISHLSHELRTPIHSVIASIQLFRSTILTVTQNEYLSIIDTSANTLLELVSNVLDYKRIRSGKLTLNNVDFNLCHVIEDVCAMVSPQAQAKSLQIASFIFIHCPLSFYGDPIRLRQVLLNLIGNGLKYTNKGQVCISVEPEQVNEHCMYLHFQVKDSGIGIKEENMSKLFAGFSQVNNGGTTQEALGSGLGLAISKDLVELMGGKIWCSSNATQNNGEAGCTFHFVIPLETNPKQLPCPIQNFNGLSVLVVDKNPYIQTVLCQYLEGWNCQVIKSSDIKEASNKLKDLRREQIEVVMIDIDNIDFRDFIQFKDAFNRLEFGRIGLITMSSDRSMVNEMGFGTSKLTKPFRQSHLVACLLASMPEHSSSTTNCFSNIVGMNSNINNNNNINNNSNNNNNNMQTHNSNSVYGNGNYGNCTPFSNNNNRIHMMSSGDKPSINNRRMSISLGKIPTFNSGGSNSPRSKKLFEEVLQQQQLQQQLQQQLQQQQQLQQQQQQQQQQQQQQQQQLQQQQQQLNTIDDDSNNYCNTTGTMDSIDEINKNNYSDSESDELNDDQAPIIAPVQQLSFGRVTRRHSIDIIMFENSRELSELRNLEDSTRYLSPRSMNNNNGNNDNGINGGSGNSLFGSSIKEEIGGTSDTSSLAQSPNSLSPRAPTKIMILDDNPVSLKLMQRILESRGFECYPFDCSEKAVAQLDQVNPAIIFMDCEMPKMNGFECTQLIRKREQESLCLLKDRKIIIALTAHINPEIQVKCFDAGMNDFISKPFKPQCLELILRKWEDCISNNQLNYNNSLINNQTTIQEQV