Protein
DENN domain-containing protein 5B
Function
Guanine nucleotide exchange factor (GEF) which may activate the small GTPases Rab. May promote the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
Similarity
Belongs to the RAB6IP1 family.
Sequence
MSATMSGSGSAPCRFAHYFIVCGLDDETGLEPDALAALYQWLEADRQGKDPEATAAGENFDQSPLKRTFKSKVLAHYPENIECNPFDQDAVNMLCMPKGLSFRTQRDSLAPHFHSFLITREDGSRTYGFVHTFYEEVTSPQICSAMQTLHQMHQAEHNTSAQNCTSSSSSSSSSSSSSSMDSLSSSLDDVDSPSAHGGRRTCEGYDSIRDTLYVSKAMCLIAPMPFMHACKRFLAQMHRAVSCSPPPPLPLESYIYNVLYEVPLPASGRSLKFHGVYEPILCQRPGVGELPLADFPLADAFRLLGVENLVQLFTCVLLEMQILLYSQDYQRLMVVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHCIELPEDFPQFPNRSEFIQELSEVLLSFGQSPEGGSSSPEPAVMSLQTSVLEKELKSTSLRELVDDKTNGNLGGEALDVLELLQGNPTLERLQALAKRTGVKVARLEALAAGQKGDEGVGGRSPVEEEELRNAKLNVQLREVFAARFATMFADYESFVIQNSPDLESWLTNREQMHNFDKASFLSDQPEPYLPFLSHFIETQMFATFIDNKIMSQWEEKEPLLRVFDGRIEKARLYNVRAPSLRSSVYQKCTFLKESAQAIEQRLRKIDHTAIHPHLLDMKIGQGKYQQGFFPKLQADVLASGPTSNKWSNRTCSTQRRVERHRQQNEHLVLDNELKEKYMQEARNLGKNLRQPKLSDLSPAVIAQTNWKFVEGLLKECKMKTKRMLVEKMGREAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQAREEKNEQQLESPVSNGQERRKTESSVGLPGLRVSVIQDMRHIQNMAEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQALTKKLYKRYAFLRCEEEKEQFLFHLLSLNAVDYFCFTSVFTTIMIPYRAVIIPIKKLSNAMTTSNPWLCVSGELGDSGILQITKNILEMTFDCQNLGKLTTVQLGHDNSGLLAKWLVDCVMVRNEITGHTYKFPCGRWLGKGVDDGSLERVLIGEFVVPCGDDEGGRGSKTPPLQRSPSQIRRISITSLTGKGNKPTTVQIQESIGEAVNNIIKHFHKPEKERGSLTVLLCGEGGLVWALEQFFHHGFRSARIFQKNVFVWDFFERIVAFMENRDQTGDLQESPEPLSLNSESLCRYVNAINNMPRNIGKDGKFQLLVCLGARDRLLPQWLPLLAESPVITRMYEENALLRDKLTVSSLLGVLETLHDFPITLETSLTKSVEL