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ddh

Gene
ddh
Protein
Meso-diaminopimelate D-dehydrogenase
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
Length
334 amino acids
Function
Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate (m-DAP), since the activity with L,L-2,6-diaminopimelate is less than 5% of the activity observed with m-DAP. Can use NAD(+) only very poorly since the activity observed in the presence of NAD(+) is about 0.3% of that with NADP(+).
Similarity
Belongs to the diaminopimelate dehydrogenase family.
Mass
37.224 kDa
Sequence
MGGVTLEKIRIGIVGYGNLGKGAELGIRQNKDMELVGIFTRRNPNSIKPLTEGVKVYSVDSARDMADKIDVMLLCSGSRTDLPVQGPEFAAMFNIVDGFDTHNKIQEYFESVDAKAKESKKVAVIACGWDPGMFSLNRLFGEVILPEGKTYTFWGKGVSQGHSDAIRRVKGVVDAKQYTIPVESAIELVRKGENPELTTRQKHIRECFVVVEEGADKERIEREIKTMPDYFADYDTIVHFISLEELKEKHSGIPHGGFSIRTGRTGINNENKHTIEYSLKLDSNPDFTANTLLAYARAAYRLNKEGVFGAKTVFDIPPAYLSPKSAEELRRSLL

Gene
ddh
Protein
2-hydroxyacid dehydrogenase homolog
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
331 amino acids
Similarity
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Mass
37.088 kDa
Sequence
MKIAIYSTKSYDRKYIELINAKYNFDLEFFDFMLNESTVRLAEHCEVVCIFVNDNGSRKVLEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTLNRRIHRAYQRTREANFSLEGLIGFNMYGRTVGVIGTGKIGIAVMRILKGFGMNILAYDPFKNPVVEELGGQYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGVMIVNTSRGSLIDTQAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQDDIFRRLSSCHNVLLTGHQAFLTEEALTNIADVTLSNIYKLKSGKVCENIVLPS

Gene
ddh
Protein
2-hydroxyacid dehydrogenase homolog
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Length
331 amino acids
Similarity
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Mass
36.496 kDa
Sequence
MRVAIFSSKNYDHHSIEKENEHYGHDLVFLNERLTKETAEKAKDAEAVCIFVNDEANAEVLEILAGLGIKLVALRCAGYNNVDLDAAKKLNIKVVRVPAYSPYSVAEYAVGMLLTLNRQISRGLKRVRENNFSLEGLIGLDVHDKTVGIIGVGHIGSVFAHIMTHGFGANVIAYKPHPDPELAKKVGFRFTSLDEVIETSDIISLHCPLTPENHHMINEETLARAKKGFYLVNTSRGGLVDTKAVIKSLKAKHLGGYAADVYEEEGPLFFENHADDIIEDDILERLIAFPNVVFTGHQAFLTKEALSNIAHSILQDISDAEAGKEMPDALV

Gene
ddh
Protein
Meso-diaminopimelate D-dehydrogenase
Organism
Ureibacillus thermosphaericus
Length
326 amino acids
Function
Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Is highly specific for meso-2,6-diaminopimelate as the electron donor, since the following amino acids are inert for the oxidative deamination reaction: DL-2-aminopimelate, D-glutamate, L-glutamate, D-aspartate, L-aspartate, D-alanine, L-alanine, D-valine, L-valine, D-lysine, L-lysine, D-phenylalanine, L-phenylalanine, D-leucine, L-leucine, D-threonine, L-threonine, D-serine, L-serine, D-tryptophan, L-tryptophan, D-cysteine, L-cysteine, D-histidine, L-histidine, D-methionine, D-arginine, D-proline, D-asparagine, D-glutamine, D-isoleucine and D-ornithine. Moreover, exclusively uses NADP as the electron acceptor for the oxidative deamination of meso-DAP; NAD is inert.
Similarity
Belongs to the diaminopimelate dehydrogenase family.
Mass
36.01 kDa
Sequence
MSKIRIGIVGYGNLGRGVEAAIQQNPDMELVAVFTRRDPKTVAVKSNVKVLHVDDAQSYKDEIDVMILCGGSATDLPEQGPYFAQYFNTIDSFDTHARIPDYFDAVNAAAEQSGKVAIISVGWDPGLFSLNRLLGEVVLPVGNTYTFWGKGVSQGHSDAIRRIQGVKNAVQYTIPIDEAVNRVRSGENPELSTREKHARECFVVLEEGADPAKVEHEIKTMPNYFDEYDTTVHFISEEELKQNHSGMPHGGFVIRSGKSDEGHKQIIEFSLNLESNPMFTSSALVAYARAAYRLSQNGDKGAKTVFDIPFGLLSPKSPEDLRKELL

Gene
ddh
Protein
Meso-diaminopimelate D-dehydrogenase
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
320 amino acids
Function
Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate, since L,L-2,6-diaminopimelate, D,D-2,6-diaminopimelate, L-glutamate, L-alanine, L-leucine, L-valine, L-aspartate, L-threonine, L-homoserine, L-methionine, L-lysine, L-serine, L-phenylalanine, L-tyrosine, L-tryptophan, L-ornithine, L-histidine, L-arginine, D-glutamate, and D-alanine are not substrates for the oxidative deamination reaction. Can use NAD(+) only poorly since the activity observed in the presence of NAD(+) is about 3% of that with NADP(+).
Similarity
Belongs to the diaminopimelate dehydrogenase family.
Mass
35.199 kDa
Sequence
MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVADVDKHADDVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQVMNEAATAAGNVALVSTGWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQGHSDALRRIPGVQKAVQYTLPSEDALEKARRGEAGDLTGKQTHKRQCFVVADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHTGMPHGGHVITTGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVLEVAPYLLSPENLDDLIARDV

Gene
ddh
Protein
D-2-hydroxyacid dehydrogenase
Organism
Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)
Length
308 amino acids
Function
Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.
Similarity
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Mass
33.336 kDa
Sequence
MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV

Gene
ddh
Protein
Meso-diaminopimelate D-dehydrogenase
Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Length
299 amino acids
Function
Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate (m-DAP), since the activity with L,L-2,6-diaminopimelate is less than 5% of the activity observed with m-DAP. Can use NAD(+) only very poorly since the activity observed in the presence of NAD(+) is about 14% of that with NADP(+).
Similarity
Belongs to the diaminopimelate dehydrogenase family.
Mass
32.327 kDa
Sequence
MKKVRAAIVGYGNIGRYVLEALQAAPDFEIAGVVRRAGAENKPAELNDYAVVKDIKELQGVDVAILCTPTRSVEKYAKEILAMGINTVDSFDIHTGIVDLRRELGACAKEHGAVSIISAGWDPGSDSIVRTMLEAIAPKGITYTNFGPGMSMGHTVAVKAIDGVKAALSMTIPTGTGIHRRMVYIELKDGYKFEEVAAAIKSDAYFVNDETHVKQVPSVDALLDMGHGVNLTRKGVSGKTQNQLFEFNMRINNPALTAQVLVCVARASMKQQPGCYTMVEVPVIDLLPGDREEWIGHLV