Protein
Dapdiamide synthesis protein DdaD
Organism
Enterobacter agglomerans
Function
Involved in dapdiamide antibiotics biosynthesis. Activates and sequesters N-beta-fumaramoyl-DAP as a covalently tethered thioester for subsequent oxidative modification of the fumaramoyl group.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Sequence
MHSVETFNLPALNSLLETTARRFGNRLAVQDDNGSLTFADFVEKVGILSAKLRLVIKRGEHVAVQLPRGINYIVAAYAIWEAGGVYLPLDNQWPSSRIEGILHRSHVRVLIHTSQADQGLELTELPAETRAESPVAGTPAYIIHTSGTTGEPKGVVVSHESLIHLVESHQRDIYQAYDVTEGPVAINASFCFDSALERMALVALGYSLHVVSDQVRKSPYELVKYLRDNSIVNVDLVPSHLKVLLSAGLNEKCDALRLVIVGGEAIDAELWREIVQNQAIYINVYGPTENTINTSFCEIRGETPHIGRPFKNVTCLLLNENGERCAAGEEGELLVAGRHLAQGYYNAPDLTDRVFVHIDGIRYYRTGDRVRQNEQGNLLYLGRIDDQVKINGFRIELADVQHNLTQLPGVKYAAVTPIKLPTGQGLLASIVWNSDAPEQTFSNLEALLGEKLPSYMVPTRWQKLDALPLTDNLKLDHKSLLSHWKNSQEQIGEKFAAESISATEHQIKNLWQKILRQPSLSPDAHFFASGGDSMAAMTLLVELKKVTPQDVSLGDIFKYPTIRKMAAWLDASSVQAES