Protein
Lariat debranching enzyme B
Function
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).
Similarity
Belongs to the lariat debranching enzyme family.
Sequence
MKIAVEGCCHGELDKIYETIQFLEKKENTKVELLLCCGDFQAVRNEGDMKCMAVPVKYRQMQTFYKYYSGEKKAPILTIFIGGNHEASNYLQELPYGGWVAPNIYYMGYAGVVKYRGVRIGGISGIFKSHDYRKGHFERLPYGKDTVRSAYHVRSIEVFKLKQLKEPMDIFLSHDWPRSIYHYGNKKQLLKKKDFFRQEVEDNTLGSPAASELLLHIQPSYWFSAHLHVKFAAFMQHQTNVDGEIPKATKFLALDKCLPRREFLQIVDVEHDSAKSECLEYDLEWLSVLKATKDLLNITPNTWNMPENNGLHSRWDFSASEETKREVVSDLGHDLKIPCNFSMTTACYDPNNPQYKRVATHIVNPQTTEFCARLGLVDLNAKICQNEEENFDIAEDNEADSIGSAEDPGEYSTDTSVLSTSVNPDEITLEDDDDQEDEGMEDKLGEPSPEYTPDLSINLSKIRVLPDSMAVSSDDATDSTNDELDRSESSQTEGEGKPSNRPLKRISDENGSGGVKIKRRNQAIYQAKDDEDE