Protein
ATP-dependent RNA helicase dbp-4
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
Sequence
MAPGGPKGRGGKGKAEKERSKANKAEHKTLKRKRELENLEALQKRIDELDPKSTELNKFSDLPLCEPTASGLRASHFEVLTDVQRAAIPLALKGQDILGAARTGSGKTLAFLVPVLEKLYRARWTEYDGLGALIISPTRELAVQIFEVLRKIGRNHSFSAGLVIGGKSLKEEAERLGRMNILVCTPGRMLQHLDQTAGFDVDNLQMLVLDEADRIMDMGFQQAVDALVEHLPKSRQTLLFSATQSKRVSDLARLSLKDPEYVSVHEAAASATPVGLQQHYIVTPLPEKLDTLWGFLRTNLKSKIIVFMSSGKQVRFVYESFKRMQPGIPLLHLHGRQKQIARLEITNRFTSAKYSCLFATDVVARGVDFPAVDWVIQVDCPEDADTYIHRVGRTARYESKGRAVLFLDPSEEEGFLKRLEHKKVTVQKVNVKENKKKSIKNELQSQCFQSPDLKYLGQKAFVSYVRSIYLQKDKEVFKFDKLDLDGFASSLGLPGTPQIRYQKGEDVKKLKNASRAAMSSGSDTEGSDGEIRKKKKEVRTKYDKMAERQNQDVLSTHYRKLLGEDQAEDNEEDDFLSVKRVLDDDAALDDAAGNAKSGTNPDGTAKVVKLGKNAELVIDSHRREKLLKSKKKLLKYMEKGQKLVFDDEGNAHPLYQLQDEEDFQKEGDAKELRQKFVESEATKVKEQDVEDKLLAKQRRKEKRERAKARERGEEVEREKGPLQPALLDAHSDVEEDPLALLRSLPVAGKGGDSGDESEDDREPPKKKAKKWFQKDDSDTEYSDDGRPRRKKAKMEGGRKVIEMDHEPDNLQDLEALAAGLLED