Protein
Diadenylate cyclase
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Function
Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. Is essential for H.volcanii. Overexpression of DacZ leads to cell death, suggesting the need for tight regulation of c-di-AMP levels. Cannot use GTP as substrate.
Similarity
Belongs to the adenylate cyclase family. DacZ subfamily.
Sequence
MAALSELLGDLVADVDGLFLFTPSSSHYEQFAETDVPTVVIAPENTVEAETFVELPLQFQNVKDRIRFGVEGAMEQSIVEAGDTIACNVGTFGGDPDSLVRVRVEENMRSGIYDLFANSRADPGVIRDVFEVAIELGKKGQKGEPVGALFIVGDAGKVMNKSRPLSYNPFEKSHVYVGDPIVNVMLKEFSRLDGAFVISDSGKIVSAYRYLEPSAEGVDIPKGLGARHMAGGAITRDTNATAIVLSESDGLVRAFKGGKMILEIDPEAY