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dacZ

Gene
dacZ
Protein
Diadenylate cyclase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
309 amino acids
Function
Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25965978). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation (By similarity).
Similarity
Belongs to the adenylate cyclase family. DacZ subfamily.
Mass
34.38 kDa
Sequence
MIAKYIIKHGLELAYDIKADAFMIFTETGKSYELLKSFLKKDEHSGIIKILDKISHKNVKIIVATPNQVTYKKISSENEENIYPIFIKHREDNRCMIISSGIVHALKMKILKENNKIVAVVGEPKTPGKLDTIMVVNVKEHVKTITLYELFETLDEKQKRTLKEIIKLAMEIGREGREGEYVGTIFVMGDTLNVMSMSKPLILNPFAGHNASIFDENVKGTIKELSSIDGAFIITDEGKVVSAGRFLEIKGDVNIPKGLGARHLAAASISKNTNAIAVTVSQSGGIVRVFKDGKIVFETDPRANILFFD

Gene
dacZ
Protein
Diadenylate cyclase
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Length
269 amino acids
Function
Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. Is essential for H.volcanii. Overexpression of DacZ leads to cell death, suggesting the need for tight regulation of c-di-AMP levels. Cannot use GTP as substrate.
Similarity
Belongs to the adenylate cyclase family. DacZ subfamily.
Mass
28.953 kDa
Sequence
MAALSELLGDLVADVDGLFLFTPSSSHYEQFAETDVPTVVIAPENTVEAETFVELPLQFQNVKDRIRFGVEGAMEQSIVEAGDTIACNVGTFGGDPDSLVRVRVEENMRSGIYDLFANSRADPGVIRDVFEVAIELGKKGQKGEPVGALFIVGDAGKVMNKSRPLSYNPFEKSHVYVGDPIVNVMLKEFSRLDGAFVISDSGKIVSAYRYLEPSAEGVDIPKGLGARHMAGGAITRDTNATAIVLSESDGLVRAFKGGKMILEIDPEAY