daam1-a

Gene

daam1-a

Protein

Disheveled-associated activator of morphogenesis 1-A

Organism

Xenopus laevis

Length

1081 amino acids

Function

Binds to disheveled (dsh) and Rho, and mediates Wnt-induced dsh-Rho complex formation during gastrulation (PubMed:11779461). May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (PubMed:26644512).

Mass

124.182 kDa

Sequence

MAPRKRNSRGVSFIFCCFRSSEHPEITYRLRNDSNFALQSMEPALPVPPVEELDAMFAELVDELDLSEKHREAMFALSAEKKWQIYCSKKKDHEEGATSWPEFYIDQLNSMAARRTLFAMDKEDEEERNKTIESLKTALRTKPMRFVTRFIDLDGLTCILNFLKSMDYEIAESQIHTSLIGCIKALMNNSQGRAHVLAHTESINVIAQSLATENIKTKVAVLEIMGAVCLVPGGHKKVLEAMLHYQRYASERTRFQTLINDLDRSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFDLVHIDTKSATQMFELIRKRLTHTESYPHFTSILHHCLQMPYKRSGNTVHYWLLLDRIVQQIVIQNEKGQDPDTSPLENFNVKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEYKNVKQQVAELTAQIQELNSRTVCAPGPGGPPPPPGAPGGPMSMPSGNFMPPPPPPPPPFPGGMAPPPPPPPPPPPPPGGPPPPPGLPLLGAAPPGAPLGLSMKKKNIPQPKNPLKSFNWSKLPDNKLEGTLWIDLDDAKVLKILDLEDIERTFSAYQRQQDFFVNNGIKQKEMDCTDDTLSSKMKVKELSVVDGRRAQNCNILLSRLKLTNEEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRDASKEVLQSKNLKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITVVEKKYPKIVNLHEELQTISVAAKVNMTELEKEISALRNGLKSVENELEYQKTQPTLPGDKFVSVVSQFITVAGFSFCDVEDLLSEAKELFVKSAKRFGEETNKIQPDEFFGIFDQFLQAFLEAKQENENIRKRKEEEERRIRMEAQLKEQRERERKARKAKENGEEEGEFDDLVSALRSGEVFDKDLSKLKRNRKRIVSQTTESSRERPVTKLNY

Protein

Disheveled-associated activator of morphogenesis 1-A: daam1-a