Protein
Cobalt-zinc-cadmium resistance protein CzcC
Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
Function
CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt.
Similarity
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
Sequence
MRRLFLPLGLAVAFLSPNFAVAQSDTGTSMVPVFPREAAGPLTLEAALSLAAGSNFNLSAAAKELDSTEGGIMQARVIPNPELKTLVEDTRKSTRTSTAQMNIPIELGGKRSARINAAERTRELAQATLAGVRGDIRAQVIESFFSVLIAQERVKLATGSADIAARGAQAASRRVAAGKISPVDETKARVEQANAELELAEATASLQSARQALTALWGNASPQFAEAQGNLDALPSRPAPELLQKELENSPLVAASRAELDRRQALVGVERSRQYPDLTVSLGAKRDTEANRNMAVIGVAIPLPIFDRNQGNLYSAIRQADKAQDEYLANRISLTRNLLMASNQLSVSRASAQTLKQTVLPGAEQAFNAATIGFEAGKFNYLDVLDAQRTLFQARIRYLGVLGQTYQAATTIDRILGR