Protein
Siroheme synthase 3
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Function
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
Similarity
In the C-terminal section; belongs to the precorrin methyltransferase family.
Sequence
MDYLPIFCRLDNKPVLLVGGGEVAERKARLLLDAGAQLTVVAPELDPELAELAANGSIEWLAGEFAPQQLTGKWLVVAATDRREVNALVYQSANQARIFANVVDDPKRSSFIMPSIIDRSPLMVAISSGGKAPVLARLLREKLEALLPQHLGAVAAFAGSLRERVKARFASMGERRRFWERLLGADRLGQALARGDSASANQLADSLFADESQSGGEVVLVGAGPGDPGLLTLHALRQMQQADVVVYDRLVSDEVMALVRRDARRIFVGKQAGNHCVPQEGINQLLLDEAKKGQRVVRLKGGDPFIFGRGGEELETLVGSGIGFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFVTAHGKGGAQDLDWPLLAKDKQTLVFYMGLSSCTTIREQLLTHGKAGDTPVALIERGTQPSQRVIRGTLAQLPELALGVESPALIMVGSVVTLADQLAWFGQGGAADAALASA