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cwn-2

Gene
cwn-2
Protein
Protein Wnt-2
Organism
Caenorhabditis elegans
Length
360 amino acids
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1 (PubMed:19855022). In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore (PubMed:19855022). Together with Wnt ligand cwn-1, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). May act through the wnt receptor cfz-2 to regulate QR neuroblast descendant migration, and to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with wnt ligand cwn-1, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Through the cam-1 receptor also probably regulates the outgrowth of neurites from RME GABAergic motor neurons (PubMed:20711352). May act redundantly with other Wnt ligands such as cwn-1 and mom-2 to control seam cell polarity (PubMed:22022276).
Similarity
Belongs to the Wnt family.
Mass
40.436 kDa
Sequence
MIPRRSCWLILLLNLLNVQSLLDASWWSTVAQLSTALAGHNVKPVCELPGLSPGQAQVCELFKDHMPAVSIGAQNAIQECQRQFTGHRWNCSTHYSTGMLGPIHKMATREAAFTYAILSAGVTHEIGRRCKQGLLTSCGCSDETKPKNVPTDWSWGGCGDNVEYGYKFSRDFIDIREKEHDPKRNHDNGRSLMNRRNNEAGRKILKRHRKPKCKCHGVSGACNMKTCWMQLPSMEQVGKILRNKYDKAIRVQINDRGNLQLLADEATKERKTRALPTDLVFMDDSPDYCRFDRHSGTLGTEGRVCKRGSGGAEGCDSLCCGRGYNTYTQEVKSKCNCKFEWCCKVVCQTCNNVTQVDICK