Organism
Dictyostelium discoideum
Function
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Appears to ensure that the proper number of prestalk cells differentiate at the appropriate time in development. May govern prestalk cell differentiation.
Similarity
Belongs to the cullin family.
Sequence
MMNGLGRQDIDFNTIWKNIADQVYKILTGSQNVSAMFLYEDVYKLCIAQPQPYCEPLYENIKKFFEQHVDQILLIILDTKSDTISEYLKQWKLFFSGCELCNKVIFRYLNLNWINKKILDKKFGHPPDVYEIQILGLMIWKERLFFKIKDRVLKCVEILIQKDRDGELVQHQFISQFMESLIKLDSVDKDRTLYLIEYEASYLENTRQFYTRESVAFIASSGISSYMKKAETRIDEEEQRSQKYLNSSSHDKMRRLLHSILIEKHKELLQSECINYLKDEKLDEIYNMYKLLSRIEGGLAPVLETVQKYIQHVGIDAIKSIPDRNNPDPKIYVETLLKIYLQFSSIIKKSFNNDVSFITVLDLACHKIFNQNHITRNTTKSPELLAKYCDMLLKKGNKQHEEIELEEKLGQIIVLFKYVDDKDVFQKFYSKMLSRRLINGTSVSDDIEKFMITGLKQACGFEYTSKFQRMFNDITLSAETNEEFKNHLIKNSLSIGKIDFSILVLTSGSWSLHSQTSSFIVPQELTLCISAFQQYYSTQHQGRKLNWLHHLCKAEAKSFFAKKSYDFQVTNFQLGILLIFNTQESVSLEEITKFTNLNENELSRTLQSLIEAKILISKKKDQNSINNNNNNNNNNNNNGEGNNSLVDSANNMQPSSSSSSTQEYTVNSAYSNKRSKVKVSSSLQKETPLQNEETYKGIDEDRKLYLQASIVRIMKARKTMNHVSLIQEVIEHSRLRFQPNIPMIKKCIEQLIEKEYITRAEGESDRYLYAA