About Products Protein Database Contact

csrA2

Gene
csrA2
Protein
Translational regulator CsrA 2
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Length
70 amino acids
Function
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
Similarity
Belongs to the CsrA/RsmA family.
Mass
7.965 kDa
Sequence
MLILTRRIGESVIIGDDIKITVLGVKGNQVRLGIDAPKDISVHREEIYERIQQEKLAQSEDQGEKTDEFE

Gene
csrA2
Protein
Translational regulator CsrA2
Organism
Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CHA0)
Length
62 amino acids
Function
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Post-transcriptionally represses the expression of genes controlled by GacA/GacS (PubMed:10570200, PubMed:15601712, PubMed:11807065, PubMed:23635605). Represses expression of hcnA; alterations in the ribosome-binding site relieve the repression (PubMed:10570200). Binds specifically to small RNAs (sRNA) RsmX, RsmZ and RsmY; these sRNAs fold into secondary structures with multiple GGA sequence in loops to which the CsrA proteins bind (PubMed:11807065, PubMed:14622422, PubMed:16286659). Binding to RsmX, RsmY or RsmZ titrates the protein so that it can no longer bind mRNA and repress translation; each sRNA can bind more than one protein (PubMed:14622422, PubMed:16286659). Required for optimal expression and stability of sRNAs RsmX, RsmY and RsmZ (PubMed:15601712, PubMed:16286659). Deletion of rsmY or rsmZ alone has no detectable phenotype, but a double sRNA deletion has a marked decrease in production of secondary metabolites HCN, exoprotease AprA, antifungal agent 2,4-diacetylphloroglucinol and protects cucumber plants from fungal infection less well than wild-type (PubMed:14622422). The triple sRNA deletion has even stronger loss of these phenotypes (PubMed:16286659).
Similarity
Belongs to the CsrA/RsmA family.
Mass
6.953 kDa
Sequence
MLILTRRCAESLIIGDGEITVTVLGVKGNQVRIGVNAPKEVAVHREEIYLRIKKEKDEEPSH

Gene
csrA2
Protein
Translational regulator CsrA 2
Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Length
62 amino acids
Function
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
Similarity
Belongs to the CsrA/RsmA family.
Mass
6.953 kDa
Sequence
MLILTRRCAESLIIGDGEITVTVLGVKGNQVRIGVNAPKEVAVHREEIYLRIKKEKDEEPSH