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csn1

Gene
csn1
Protein
COP9 signalosome complex subunit 1
Organism
Xenopus laevis
Length
487 amino acids
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Similarity
Belongs to the CSN1 family.
Mass
55.272 kDa
Sequence
MPLPVQVFNLQSAVEPMQIDADPQDDQQNMPDVNYVVENPTLDLEQYASSYSGLMRIERLQFIADRCPQLRVEALKMALSFVQRTFNVDVYEDIHRKLAEASREVQNAPDAVPEGSMEPPALDTSWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAVLTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEIKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMYKMATAFNTTVSALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGREFQRRAKAMILRAAVLRNQIHVKSPPREGSQGELTPANSQSRLSTNM

Gene
csn1
Protein
COP9 signalosome complex subunit 1
Organism
Dictyostelium discoideum
Length
458 amino acids
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Similarity
Belongs to the CSN1 family.
Mass
53.067 kDa
Sequence
MEDMQVEKNTEGSSSSSSNNNNNNSISNEFDLETYINNYSGFTKIHRLIFIADNCKQLEVEAYNMALKEVQKTPNLELYNTIINKSHGILELDPVYIENLSKKNSLQLDKLEQDLNTAKSNMVKDSIRFAQNDLGEFYYKIGDHQNALKCFIRTRDYCTTSKHVLAMCFNIIKLGVDTQNYTHAPSYIAKAEQSPDLDNVSNAKLRSVNGLYNLDGSRYKLAARKFIETPFEQSNVFSDIISPQDIAYYGGLCALATFDRNELKKKVIDDPMFKNYLELVPELRELINDFYNTKYGSCLKYLDKMKPILLLDIHLYKHVEILYQRIRSKALVQYFSPYQSVDMNIMASAFNTTVTLLEKEISKLIMENEIQARIDSHNKRLYARKADQRTTTFEKTVQVGSDFQNSSNSLLLRLEMLNNNISTVSNRKDNERGNWENPHHHHQMQHQMFGLFNNNNKF

Gene
CSN1
Protein
COP9 signalosome complex subunit 1
Organism
Arabidopsis thaliana
Length
441 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. In the complex, it plays a central role in CSN assembly.
Similarity
Belongs to the CSN1 family.
Mass
50.579 kDa
Sequence
MERDEEASGPMMEMCTNGGEETSNRRPIISGEPLDIEAYAALYKGRTKIMRLLFIANHCGGNHALQFDALRMAYDEIKKGENTQLFREVVNKIGNRLGEKYGMDLAWCEAVDRRAEQKKVKLENELSSYRTNLIKESIRMGYNDFGDFYYACGMLGDAFKNYIRTRDYCTTTKHIIHMCMNAILVSIEMGQFTHVTSYVNKAEQNPETLEPMVNAKLRCASGLAHLELKKYKLAARKFLDVNPELGNSYNEVIAPQDIATYGGLCALASFDRSELKQKVIDNINFRNFLELVPDVRELINDFYSSRYASCLEYLASLKSNLLLDIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKELEALITDNQIQARIDSHNKILYARHADQRNATFQKVLQMGNEFDRDVRAMLLRANLLKHEYHARSARKL

Gene
csn1
Protein
COP9 signalosome complex subunit 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
422 amino acids
Function
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair.
Similarity
Belongs to the CSN1 family.
Mass
48.657 kDa
Sequence
MSLNLLVNQEELKRYLDEYGVWSKIFRALFVARNSKPLRSFCVHYAIKELKEKTYNLELYQSLFEEFQDCFENEQLDVEWVESVTFHRKQNLEQLRRELKAYKNNLIRESIRAAQLDLASFFADVGQFDSALRSYAKVREYCTNAGQIAHLSLELMRISIWIGNYSHVLAFGSRAKSTVSAAMELTSPIYAYCGLANFCLGDYEEALAHFLKVETDTSDGIITKTDISVYISLCALACWDHKRLIQELERNEEFNALSDLDPSLRRCLQAKCNRKYSLLLDTLQQNAQDYSLDMYLAPQLTNLFSLIRERSLLDYLIPYSALPFSKIAVDFHIDENFIEKNLLEIIEAKKLNGKVDSLQKRVYIEPSSEPENFEDIKNIAQTSLLYSKALYLQTLAAMNTENTDDEAPVIAQTNITAEDSQN

Gene
CSN1
Protein
COP9 signalosome complex subunit 1
Organism
Brassica oleracea
Length
37 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes (By similarity).
Similarity
Belongs to the CSN1 family.
Mass
4.336 kDa
Fragment
single
Sequence
ELEALLITDNQIQARIDSHNKILYARHADQRNATFQK