Protein
N-terminal acetyltransferase B complex subunit NAA25 homolog
Organism
Caenorhabditis elegans
Function
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Required for chromosome organization and arrangement; specifically for assembly of the central region components of the synaptonemal complex onto chromosomes during meiosis and for DNA double stranded break formation and repair (PubMed:18535664, PubMed:25768301). Acts downstream of xnd-1 to regulate levels of histone acetylation in germ and somatic cell nuclei by controlling acetyl-CoA production through antagonizing the acetyl-CoA hydrolase activity of acer-1 (PubMed:25768301).
Similarity
Belongs to the MDM20/NAA25 family.
Sequence
MSKAELAVLERRLRPIYDSLDSQQFKKALSDCDKVLKKHPNTSAAKVLKALTLIRLEKLADATEILEALDVPGAHHDELTLQAFVHCYRDSNQHMKVVTLYERIIQVDPSEHNLTQLFMAYSREKMYKEQQKIGMRLYKDFGNAPYYFWSVMSLIMQAQENPELGKKMLLPLADKMCQTQVEKSGYTEGSSAELDLQLLILEGQEKWKECAAFLDRPQASVLPMAPYNLVEKGMDFLMKDKQYKRVDQLAMEAVTKMPDNWNLWKIITESTICQIEQCLESDNKENIELAHNFVKRLGLLIEKVQKQVGYKSRAPFIATFFAYKQIGKLTKQIPDMDDMTSIFGEQVDKMLEYAKNFYKKPVCFADLQMFFCDLTSEQKSNFLKGIDLWIGEVSAKDDVEGDESKVWAIILTERCRRALGEYEKMDAAGHRSLFQQCIAQIAAPERTEHAQGVLCNLTVSHLWDAYRKENDLTKFYEMILLLEFVAASNKTDPMCKLALIRAYSALCATGRISALVKTLDIKVIQMDTLGHLTFPVYETSGRFNLAIIQNTQLSLMYEQAEKEIQDCIAQAYRNGKFSAIPRMTAASKHMKLSAQKTACDVMNRYLSSLFVLDDVDQITVTLWGDEDPIGEKRIDWKQLIDTRDFNAIPYTETEEYEALLDDMKKRTFKELIDISELRSTLCRALGAVGRVTHENMEPRLARLQLKMTVMEFKQHLEYCCREYPSFLIPSKLAQSPAPHHLSQWVHSGGLQMVLEYLEAAVKLVDILDSGEHPEKSLVGTRTEMATKLIKLIEIPPKRKEGEKLPPFWIVDPIIKSSRALQTIAAIQVVLRLIEKVVLKLVKNVPTAVPEPVGKGKGKKDKKAAEEAMTKALDECKAVVFLEHIRAMHVELRSAGNFLHTYLGQMLALEDEYIPSNIGEDLGGAKAALEGMHNPVASRLQRSFLNTCEDMHTTIKLRF