Protein
Probable cleavage and polyadenylation specificity factor subunit 2
Organism
Caenorhabditis elegans
Function
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.
Similarity
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
Sequence
MTSIIKLKVFSGAKDEGPLCYLLQVDGDYILLDCGWDERFGLQYFEELKPFIPKISAVLISHPDPLHLGGLPYLVSKCGLTAPVYATVPVYKMGQMFIYDMVYSHLDVEEFEHYTLDDVDTAFEKVEQVKYNQTVVLKGDSGVHFTALPAGHMLGGSIWRICRVTGEDIVYCVDFNHKKERHLNGCSFDNFNRPHLLITGAHHISLPQMRRKDRDEQLVTKILRTVRQKGDCMIVIDTAGRVLELAHLLDQLWSNADAGLSTYNLVMMSHVASSVVQFAKSQLEWMNEKLFKYDSSSARYNPFTLKHVTLCHSHQELMRVRSPKVVLCSSQDMESGFSRELFLDWCSDPRNGVILTARPASFTLAAKLVNMAERANDGVLKHEDRLISLVVKKRVALEGEELLEYKRRKAERDAEETRLRMERARRQAQANESDDSDDDDIAAPIVPRHSEKDFRSFDGSENDAHTFDIMAKWDNQQKASFFKTTKKSFPMFPYIEEKVKWDDYGEVIKPEDYTVISKIDLRKGQNKDEPVVVKKREEEEEVYNPNDHVEEMPTKCVEFKNRVEVSCRIEFIEYEGISDGESTKKLLAGLLPRQIIVVHGSRDDTRDLVAYFADSGFDTTMLKAPEAGALVDASVESFIYQVALSDALLADIQFKEVSEGNSLAWIDARVMEKEAIDNMLAVGTSNLMIDDKNREEDVNDQEENGATEGEGNAEPMEIGENGSQESLAISESGKEVENGHTNDSRTKKGTKGKIRGNLILDPLPKRLIPIHQAVFVNDPKLSDFKNLLTDKGYKAEFLSGTLLINGGNCSIRRNDTGVFQMEGAFTKDYYKLRRLFYDQFAVL