Protein
Cyclopentanone 1,2-monooxygenase
Organism
Comamonas sp. (strain NCIMB 9872)
Function
Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH as an electron donor. Converts cyclopentanone to 5-valerolactone, a step in the degradation pathway of cyclopentanol. Besides cycloalkanones, can also act on methylated and other alkylated cycloalkanones, and on methylated cycloalkenones, with high enantioselectivity in some cases. Cannot use NADH instead of NADPH.
Similarity
Belongs to the FAD-binding monooxygenase family.
Sequence
MTTMTTMTTEQLGMNNSVNDKLDVLLIGAGFTGLYQLYHLRKLGYKVHLVDAGADIGGIWHWNCYPGARVDTHCQIYQYSIPELWQEFNWKELFPNWAQMREYFHFADKKLDLSKDISFNTRVQSAVFDEGTREWTVRSIGHQPIQARFVIANLGFGASPSTPNVDGIETFKGQWYHTALWPQEGVNMAGKRVAIIGTGSSGVQVAQEAALDAKQVTVYQRTPNLALPMHQKQLSAEDNLRMKPELPAAFERRGKCFAGFDFDFIAKNATELSAAERTEILEELWNAGGFRYWLANFQDYLFDDKANDYVYEFWRDKVRARIKDPKVAEKLAPMKKPHPYGAKRPSLEQWYYEIFNQNNVTLVDVNETPVLRITEKGIVTAEGEAEFDLIVFATGFDAVTGGLTSIDFRNNQGQSFKDVWSDGIRTQLGVATAGFPNLLFGYGPQSPAGFCNGPSSAEYQGDLLIQLMNYLRDNNISRIEAQSEAQEEWSKLIADFWDSSLFPRAKSWYQGSNIPGKKVESLNFPLGLPTYISKFNESAEKGYAGFSLAS