cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Serratia proteamaculans (strain 568)

Length

274 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.878 kDa

Sequence

MYRLAAFDMDGTLLTPDHRVGPETLAVLKQLVEREMVVTFATGRHYLDAQPIMAQLGLQGYLITGNGTRVYDDRGQQLQATDLPADIAEEVLHTHWHTDASMHVFRDEGWMTEFAVPEEMLRAHHLSGFHYQLTELRRLPAFGNSKVCFAGPHEELLKLQVQLRRHFAARVDLCFSAYECLEVLPLGCNKGSALDMLSRHLGLKMAECMAFGDAMNDKEMLATVGHGVVMGNALPQLKSLLPQLQVIGHCEQQAVAHYLQHWLRSPYLTYSPEL

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pestis

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.482 kDa

Sequence

MYRLAAFDMDGTLLMRDHKIGSITLNALHQLADAGVTLTFATGRHYLDMKGILSHSGLNGYLITGNGTRVCDAEGNPLYGMDLPAELVEFVLRTPWQTNASIHLFRDDGWFTDRNDPDLLIAHTTSGFHFQLTEWDELPLTGNHKFCFIASHQELVELKAQLEQQMGGEADFCFSATDCLEVLPRGCNKGVALEKLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQIIGRCEQQGVAHYLHHWLSSPHLTYSPEF

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pestis bv. Antiqua (strain Angola)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.482 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pestis bv. Antiqua (strain Nepal516)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.482 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pestis (strain Pestoides F)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.482 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pseudotuberculosis serotype I (strain IP32953)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.54 kDa

Sequence

MYRLAAFDMDGTLLMRDHKIGSITLNALHQLADAGVTLTFATGRHYLDMKGILSHSGLNGYLITGNGTRVCDAEGNPLYGMDLPAELVEFVLRTPWQTNASIHLFRDDGWFTDRNDPDLLIAHTTSGFHFQLTEWDELPLTGNHKFCFIVSHQELVELKAQLEQQMSGEADFCFSATDCLEVLPRGCNKGVALEKLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQIIGRCEQQGVAHYLHHWLSSPHLTYSPEF

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.512 kDa

Sequence

MYRLAAFDMDGTLLMRDHKIGSITLNALHQLADAGVTLTFATGRHYLDMKGILSHSGLNGYLITGNGTRVCDAEGNPLYGMDLPAELVEFVLRTPWQTNASIHLFRDDGWFTDRNDPDLLIAHTTSGFHFQLTEWDELPLTGNHKFCFIASHQELVELKAQLEQQMSGEADFCFSATDCLEVLPRGCNKGVALEKLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQIIGRCEQQGVAHYLHHWLSSPHLTYSPEF

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.467 kDa

Sequence

MYRLAAFDMDGTLLMRDHRIGGATLNALHQLVDNGMILTFATGRHYLDMKGILSHSGINGYLITGNGTRVCDMDGMHLDGMDLPAELVEFVLRTPWQTNASIHIFRDDGWFTDYNDPALLAAHKTSSFQFQLTALDALPKTGNHKICFIAPHQELAELKIQLEQHMGDQADFCFSAVDCLEMLPRGCNKGAALERLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQVIGRCEEQGVAHYLQHWLSSPHLTYSPEF

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.512 kDa

Sequence

MYRLAAFDMDGTLLMRDHKIGSITLNALHQLADAGVTLTFATGRHYLDMKGILSHSGLNGYLITGNGTRVCDAEGNPLYGMDLPAELVEFVLRTPWQTNASIHLFRDDGWFTDRNDPDLLIAHTTSGFHFQLTEWDELPLTGNHKFCFIASHQELVELKAQLEQQMSGEADFCFSATDCLEVLPRGCNKGVALEKLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQIIGRCEQQGVAHYLHHWLSSPHLTYSPEF

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pestis bv. Antiqua (strain Antiqua)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.482 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Yersinia pseudotuberculosis serotype IB (strain PB1/+)

Length

273 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.542 kDa

Sequence

MYRLAAFDMDGTLLMRDHKIGSITLNALHQLADAGVTLTFATGRHYLDMKGILSHSGLNGYLITGNSTRVCDAEGNPLYGMDLPAELVEFVLRTPWQTNASIHLFRDDGWFTDRNDPDLLIAHTTSGFHFQLTEWDELPLTGNHKFCFIASHQELVELKAQLEQQMSGEADFCFSATDCLEVLPRGCNKGVALEKLSHHLDLTLADCMAFGDAMNDKEMLSRVGRGLVMGNALPQLKQELPQLQIIGRCEQQGVAHYLHHWLSSPHLTYSPEF

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.204 kDa

Sequence

MARLAAFDMDGTLLMPNHHLGHETLATLARLRERDITLTFATGRHVLEMRHILGAISMDAFLITGNGTRIHSQEGDMLHRQDLDPAIADRVLHQAWDTRASMHVFNDNGWFTGSAIPALLQAHVYSGFHYQIVDVKRIPAHQVTKICFCGDHDDLIRLRIQLNEALGERANLCFSAVDCLEVLPLGCNKGSALAVLSDHLGLSLTECMAFGDAMNDREMLESVGRGLIMGNAMPQLIAELPHLSVIGHCRNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Cronobacter sakazakii (strain ATCC BAA-894)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

29.883 kDa

Sequence

MARLGAFDMDGTLLMPDHQLGEATQMALHRLHQRGVTLAFATGRHLLEMRQMLQKIALEAFLITGNGTRIHAPSGELLFAEDLSPQVAEAVLHGYWDTSASLHVFNDSGWLTDNDDPALLDAHAWSGFRYQLTDLKRLPAHQVTKICFVADHDALCELRVKLCQTLGSQAHICFSALDCLEVLPPGCNKGAALQALSQHLGITMADCMAFGDAMNDREMLSLAGKGLIMGNAMPQLLAELPHLPVIGHCSRQAVAHYLTHWLDHPHLDYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O139:H28 (strain E24377A / ETEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O127:H6 (strain E2348/69 / EPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O45:K1 (strain S88 / ExPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain 55989 / EAEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.34 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGRVTKICFCGGHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O157:H7

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.303 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGAISLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLHEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O157:H7 (strain EC4115 / EHEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.303 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O7:K1 (strain IAI39 / ExPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O81 (strain ED1a)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.358 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKENPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAVLTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O8 (strain IAI1)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.345 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGCVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain K12 / MC4100 / BW2952)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.371 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLVSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella gallinarum (strain 287/91 / NCTC 13346)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGRETIATLARLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella heidelberg (strain SL476)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella newport (strain SL254)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.134 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGRETIATLARLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNETLEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella paratyphi A (strain ATCC 9150 / SARB42)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella paratyphi A (strain AKU_12601)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella schwarzengrund (strain CVM19633)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.105 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGRETIATLARLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVINIKSIPAHQVTKICFCGDHDDLIRLRIQLNEAMEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLAVIGHCGNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella typhi

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.12 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGRETIATLSRLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Shigella flexneri serotype 5b (strain 8401)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.402 kDa

Sequence

MARLVAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKESPALLQVFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVRTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Shigella flexneri

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.402 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Shigella sonnei (strain Ss046)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain K12 / DH10B)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.371 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLVSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O9:H4 (strain HS)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O1:K1 / APEC

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.33 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKENPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain K12)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5-hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3-HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (MeO-TPP) and CF3-HMP-PP. Also hydrolyzes pyridoxal-phosphate (PLP) and flavin mononucleotide (FMN), and purines (GMP and IMP) as secondary substrates.

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.371 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLVSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.345 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGCVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain SE11)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain SMS-3-5 / SECEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain UTI89 / UPEC)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.329 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Enterobacter sp. (strain 638)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.209 kDa

Sequence

MARLAAFDMDGTLLMPDHRLGDKTLSTLKRLHDRDITLTFATGRHVLEMRHLLGALSLDAFLITGNGTRIHSVEGEVLHRQDLDPDVADLVLHSTWETEASIHVFNDTGWLTGKEIPELLHAHVYSGFRYQLTDLRRIPAHSVTKICFCGDHDDLCRLRIQLNDALGNRAHLTFSAMDCLEVLPVGCNKGSALAVLSDHLGLTLQDCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAELSHLPVIGHCRNEAVSHFLTHWLDQPNLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.409 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHVLEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLDRVTKICFCGDHDDLTRLQIQLHEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Klebsiella pneumoniae (strain 342)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.445 kDa

Sequence

MAKLAAFDMDGTLLMPDHRLGEQTLTALKRLRERNITLTFATGRHVLEMHHVIGEFSLDAFLITGNGTRIHSLEGEELYRQDLAPEAAEAVLHSKWDTQASMHVFNDGGWFTGQARPELLKAHAFSGFHYQLCDPKRMPAHHVTKICFCGDHDDLRRLRIQLNETLGDRAFLCFSAMDCLEVLPVGCNKGAALAVLSQHLGFTLQECMAFGDAMNDREMLGSVGRGFIMGNAMPQLKAELPHLQVIGDCRHQAVSHFLTHWLDNPDLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.359 kDa

Sequence

MAKLAAFDMDGTLLMPDHRLGEKTLSALKRLRERDITLTFATGRHVLEMHHVIGEFSLDAFLVTGNGTRIHSLEGEELYRQDLAPEAAEAVLHGKWDTQASMHVFNDGGWFTGQARPELLQAHVFSGFHYQLCDLKRMSAQHVTKICFCGDHDDLRRLRIQLNETLGDRAFLCFSAMDCLEVLPVGCNKGAALAVLSQHLGFTLQECMAFGDAMNDREMLGSVGRGFIMGNAMPQLKAELPHLPVIGDCRNQAVSHFLTHWLDNPDLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella agona (strain SL483)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.118 kDa

Sequence

MARLAAFDMDGTLLMPEHHLGRETIATLARLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.065 kDa

Sequence

MARLAAFDMDGTLLMPDHQLGRETIATLSRLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLYRQDLDPQVADTVMHHAWDTGASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVMKICFCGDHDSLIRLRIQLNETLEERAHLCFSAVDCLEVLPLGCNKGSALAVLSDHLGLSLADCMAFGDAMNDREMLGSVGQGLIMGNAMPQLIAALPHLSVIGHCGHQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella choleraesuis (strain SC-B67)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.073 kDa

Sequence

MARLAAFDMDGTLLMPDHHLGRETIATLSRLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGGNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella dublin (strain CT_02021853)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Salmonella enteritidis PT4 (strain P125109)

Length

272 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

30.104 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Shigella boydii serotype 4 (strain Sb227)

Length

260 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

28.83 kDa

Sequence

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

HMP-PP phosphatase

Organism

Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

Length

255 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

28.463 kDa

Sequence

MESLPKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

HMP-PP phosphatase: cof

Gene

cof

Protein

Putative HMP-PP phosphatase

Organism

Shigella dysenteriae serotype 1 (strain Sd197)

Length

148 amino acids

Function

Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

Similarity

Belongs to the HAD-like hydrolase superfamily. Cof family.

Mass

16.353 kDa

Sequence

MPVHLNQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE

Protein

Putative HMP-PP phosphatase: cof