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cobO

Gene
cobO
Protein
Corrinoid adenosyltransferase
Organism
Sinorhizobium sp
Length
214 amino acids
Function
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).
Similarity
Belongs to the Cob(I)alamin adenosyltransferase family.
Mass
24.028 kDa
Sequence
MSDETTVGGEAPAEKDDARHAMKMAKKKAAREKIMATKTDEKGLIIVNTGKGKGKSTAGFGMIFRHIAHGMPCAVVQFIKGAMATGERELIEKHFGDVCQFYTLGEGFTWETQDRARDVAMAEKAWEKAKELIRDERNSMVLLDEINIALRYDYIDVAEVVRFLKEEKPHMTHVVLTGRNAKEDLIEVADLVTEMELIKHPFRSGIKAQQGVEF

Gene
cobO
Protein
Corrinoid adenosyltransferase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
203 amino acids
Function
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).
Similarity
Belongs to the Cob(I)alamin adenosyltransferase family.
Mass
22.292 kDa
Sequence
MNESPEKDQRHRERMERKKAVVDEKIAQARDERGVLLVHSGNGKGKSSSAFGMVARALGHGMKVGVVQFIKGAASTGEEAFFRRFPEEVSYHVMGEGFTWETQDRQRDIAKAEAAWKVAAQLLADPDVGLVVLDELNIALKHGYLELDRVLADIQARPAMQHVVVTGRGAQPGMIEAADTVTEMSLVKHAFKAGIKAQKGVEF

Gene
cobO
Protein
Cobalamin adenosyltransferase
Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
Length
184 amino acids
Function
Adenosyltransferase that catalyzes the conversion of cob(II)alamin to adenosylcob(III)alamin (AdoCbl) in the presence of ATP and an electron donor. Acts as an accessory protein of IcmF that functions in cofactor repair, since IcmF is prone to inactivation during catalytic turnover due to the occasional loss of the 5'-deoxyadenosine moiety and formation of the inactive cob(II)alamin cofactor in its active site. Thus, receives and repairs the inactive cofactor, which is then reloaded onto IcmF in a GTPase-gated step.
Similarity
Belongs to the Cob(I)alamin adenosyltransferase family.
Mass
19.904 kDa
Sequence
MGNRLSKIATRTGDAGTTGLGDGSRVGKNSLRIVAIGDVDELNSHIGLLLTEPDLPEDVRAALLHIQHDLFDLGGELSIPGYTLLKAPQVAQLDDWLAHYNAALPRLAEFILPGGSRPAAQAHICRTVCRRAERALVELGAAEALNEAPRQYLNRLSDLLFVLARVLNRAGGGSDVLWQRERES