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cmlI

Gene
cmlI
Protein
Non-heme di-iron N-oxygenase
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Length
339 amino acids
Function
Involved in chloramphenicol biosynthesis (PubMed:24347692, PubMed:25564306). Catalyzes the six-electron oxidation of an aryl-amine precursor of chloramphenicol (NH2-CAM) to yield the aryl-nitro group of chloramphenicol (CAM) (PubMed:24347692, PubMed:25564306, PubMed:27203126). During catalysis, upon exposure of the diferrous cluster to O(2), ClmI forms an exceptionally long-lived peroxo intermediate (CmlI-peroxo), which reacts with NH2-CAM to form CAM (PubMed:25564306, PubMed:27203126).
Mass
38.249 kDa
Sequence
MRDHTDEKSEAAGNDDGHVRIGGLPAFDPDDPAENAVINRLVGNWHRRAAVKREEPDVYALFDPGRPDFREDMIPFRGHPIWERLSDETRSRLLSWGWVAYNRNTVLIEQRIANPAFELVIGGAYPGLGGQQLELAVAQAMVDEQYHTLMHINGSAVTRRMRRSDFSDRVLPDSHITTIHQEHLDRCEEPWQRSLTTLGFATVAEISINAYLDLLADDQEIQVVNSTTVKLHNRDEYCHASISGEMMKQVYEALPADRRRFLLEKVVAGLEAFVAPDFTTWESIVAFEGVPGWEKAAAEVREAQGGTHLVQDHSGIHTLLTEMDVLDQVEFGWGTTVTR