cldD

Gene

cldD

Protein

(12E)-labda-8(17),12,14-triene synthase

Organism

Streptomyces cyslabdanicus

Length

329 amino acids

Function

Involved in the biosynthesis of the mercapturic acid derivative diterpene cyslabdan A, a potentiator of the beta-lactam antibiotic imipenem (PubMed:26507838). Catalyzes the conversion of (+)-copalyl diphosphate to yield labda-8(17),12(E),14-triene (biformene) (PubMed:26507838, PubMed:26814669).

Similarity

Belongs to the terpene synthase family.

Mass

35.699 kDa

Sequence

MTRTGDAVTILPQPDFTATFPGPFPTSPHGERTERQLLGWLEEYPLLPSARARSVLVNITSHGVSRTLPTADADDLVLFAELLLWLTAFDDMHGESNAARDLVALVDRTAELTLVLAGGSPPPLTNPFPAALYDLLARFRARTGPAAYLRLAASLRDTIMALVWEAHHVAEPERVALETYLEMRPHTVFVRTIFAAAEIVLDYELTDAQRALAPVRHLETAVANLAGWINDLASYEREAARGPAQPLSLPTLLRARHGGSLEEAFARAGGMCENEAAVARQGITSLAGDPPSALTAHARALEDIARSFVWHTSHARYQGPKRGAAPTSR

Protein

(12E)-labda-8(17),12,14-triene synthase: cldD