Protein
H(+)/Cl(-) exchange transporter ClcA
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Function
Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
Similarity
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
Sequence
MSTRETFKISLLAKMPKDVINQFLSKDKTPFSVLFLSLLVGILAGLVGTYFEQAVHLVSETRTDWLKSEIGSFLPLWLAAFLISAFLAFIGYFLVHRFAPEAAGSGIPEIEGAMDGMRPVRWWRVLPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMISDIFRVKNEDTRHSLLAAGAAGGLAAAFNAPLAGIMFVIEEMRPQFRYTLISVRAVIISAVAANIVFRVINGQDAVITMPQYDAPELSTLGLFLLLGALFGVFGVLFNYLITLAQDLFVKFHRNDRKRYLLTGSMIGGCFGLLLLYVPELTGGGISLIPTITNGGYGAGILLLLFVGRIFTTLLCFGSGAPGGIFAPMLALGTLFGYAFGLIAKVWFPELNIEPGMFAIAGMGALFAATVRAPITGILLVIEMTNNYHLILPLIITSLGAVIFAQLLGGQPIYSQLLHRTLKNQKLQQQDLPPQSPNS