Function
Negative cell-cycle regulator that functions at the G1-to-S-phase transition (PubMed:10587644, PubMed:9716524). Required for suspension of the cell cycle in dauer larvae and starved L1 larvae (PubMed:10587644, PubMed:9716524). In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage (PubMed:10587644, PubMed:9716524, PubMed:15247923). Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation (PubMed:10587644). Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa (PubMed:17476329).