About Products Protein Database Contact

cif-1

Gene
cif-1
Protein
COP9/Signalosome and eIF3 complex-shared subunit 1
Organism
Caenorhabditis briggsae
Length
390 amino acids
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-1 targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Similarity
Belongs to the eIF-3 subunit M family.
Mass
44.102 kDa
Sequence
MADTRELPVFAYIDDIKQLQELRQYLNKHESVKLDPTGPAETAKNLVEICSTLHVLPLWSQDVDLVLNSISSLIVVVPGEKCEPVVDAFIKNVSPKFYKGIGWGSHAGIAVRVLSNLYKGYSNFHTVQEKIFMALVDMCAEARLIGELECNLETLHDRFNTWQTPVEGQREILRAVHRALLVDQRADQAAKVMTALLGTYTEKDAATARDDAMECVRTAVVDPKSFSFDHLERLSAVKALKSSDPLMFTALELFISGTLKDYQQFVAKNPKFVTDYLKVDEVILLKKIRLLTLMSLAEEKNEIKLDELAKQLDIHADETLEEFVIDAIQVNAISGKINEMANTLIVSSYQHRRFGSDQWVLLEKRLKVLIANLKQTHNNVHEVNQRIEAL

Gene
cif-1
Protein
COP9/Signalosome and eIF3 complex-shared subunit 1
Organism
Caenorhabditis elegans
Length
390 amino acids
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (PubMed:17403899). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF (PubMed:17403899). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-1 targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3 (PubMed:17403899).
Similarity
Belongs to the eIF-3 subunit M family.
Mass
44.084 kDa
Sequence
MADTRELPVFAYIDDVKQLQELRQYLNKHDSVKLDPNGPSETAQNMIEICSTLNVLPSWSQDVDLVLNSISSLIVVVPGEKCEPVVDSFIKNVAPQFYKGTGWASHAGIAVRVLSNLYKGYSNFHTVQEKIFKALVDMCAEARLIGELECNLETLQDRFNTWKTPVEGQREILRAVHRALLVDQRVDQAAKVMTALLGTYTEKDAAAARDDAMECVRTAVVDPKSFSFDHLERLSAVKALKTSDPLMFTALELFISGTLKDYKEFVAKNPKFVTEHLKVDETILLKKIRLLTLMSLAEEKNEISLDELAKQLDILADETLEEFVIDAIQVNAISGKINEMARTLIVSSYQHRRFGTEQWVLLEKRLKVLIANLKQTHNNVHEVNQRIEAL