Ciao1

Probable cytosolic iron-sulfur protein assembly protein Ciao1

341 amino acids

Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

Belongs to the WD repeat CIA1 family.

38.235 kDa

MGKLELLQTLTGHAGRVWSAAWHPGGKLFASCGEDKTIRVWNKSDTDRWVAQTVLTDGHTRTIRELAWSCCGHYLASASFDTTVAVWDKKSGEFECNATLEGHDNEVKSVTWSRSGNLLATCSRDKSVWIWEIHHAPDQEDEYECVAVLNGHTQDVKKVCWHPQEDLLASASYDNTIRMYRQDLADSEWEMLEPLESHSSTVWSISFDATGQRLASCSEDTTVKVWQQYGPDNALGIPCPDRGTIWKCVCTLSGYHSRSVYDIDWCKQTGLLATACGDDTVRIFREASDSDRNEPTFELVVTVEAHSQDANKVAWHPTVPGLLLTASDDGEIKLWQYVDAD

CIAO1

Probable cytosolic iron-sulfur protein assembly protein CIAO1

339 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).

Belongs to the WD repeat CIA1 family.

37.773 kDa

MKDSLVLLSRILAHPDSRCWFLAWNPAGTLLASCGGDRSVRIWGREGDSWICKSVLCEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNEDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSEASWKCVCTLSGFHSRTIYDVAWCQLTGTLATACGDDAIRVFEEDPGSDPQQPTFSLTAHVPQAHSQDVNCVAWNPKERGLLASCSDDGELAFWKYQPSEGI

CIAO1

Probable cytosolic iron-sulfur protein assembly protein CIAO1

339 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).

Belongs to the WD repeat CIA1 family.

37.84 kDa

MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL

Ciao1

Probable cytosolic iron-sulfur protein assembly protein CIAO1

339 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).

Belongs to the WD repeat CIA1 family.

37.633 kDa

MKDSLVLQSRVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHTRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWEYHQPAGL

Ciao1

Probable cytosolic iron-sulfur protein assembly protein CIAO1

339 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).

Belongs to the WD repeat CIA1 family.

37.618 kDa

MKDALVLQSRVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCVCTLSGFHTRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEAGLLASCSDDGEVAFWEYHQPAGL

Ciao1

Probable cytosolic iron-sulfur protein assembly protein Ciao1

337 amino acids

Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

Belongs to the WD repeat CIA1 family.

37.538 kDa

MGKLELLQCLTGHRGRAWGAGWHPKGNVLATCGEDKTIRIWAEDASQRWVAKTVLSDGHSRTIRDVAWSPCGQYLASASFDATVAIWDKKSGEFECNATLEGHENEVKSVSWSKSGSLLATCSRDKSVWVWEVAQEDEYECAAVLNTHTQDVKKVEWHPHEDILASASYDNTIKLYKEDLADSDWSSFDTLVSHESTVWSISFDGSGNRLASCSDDQTVKIWQEYKPGNEFGVSCPDNTPVWKCVCTLAGYHSRSVYDISWCKQSGLLATACGDDMVRIFKEVEGSSPHEPTFEMVGSKHAHSQDVNTVEWNPTVVGLLVTTSDDGDVKLWKYEPEE

Ciao1

Probable cytosolic iron-sulfur protein assembly protein Ciao1

335 amino acids

Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

Belongs to the WD repeat CIA1 family.

37.08 kDa

MGRLILEHTLQGHKGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREIQWSPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDEFECAAVLNSHTQDVKRVVWHPTKEILASASYDNTIKMYAEEPIDNDWDCTATLTSHTSTIWGIDFDADGERLVSCSDDTTVKIWRAYHPGNSAGVATPDQQTVWKCVCTLSGQHSRAIYDVSWCKLTGLIATACGDDGIRIFKETSDSKPDEPTFEQLTAEESAHDQDVNSVQWNPVVAGQLISCSDDGTIKIWKVTE

ciao1

Probable cytosolic iron-sulfur protein assembly protein ciao1

333 amino acids

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.

Belongs to the WD repeat CIA1 family.

37.479 kDa

MKDTLTLLSRVSAHPDSRCWFLAWNPSGTLLASCGGDRTIRIWGKDGDNWVCKSVLGEGHQRTVRKVSWSPCGNYLASASFDATTCIWMKKKEEFECITTLEGHENEVKSVAWAPSGSLLATCSRDKSVWVWEVDEEEEYECVSVLNSHTQDVKHVVWHPNQELLASASYDDSVKLYREEEDDWVCCATLEGHTSTVWSLAFDQTGEQLATCSDDKTVRIWRQLGTGEQGSKSDPNWKCVCTLTGYHTRTVYDVNWNHLTGAIATACGDDAVRIFEEDPGSDPLQPTFSLTAHMPRAHTQDVNCVTWHPKEPNLLASCSDDGEMAFWRYQKPE