Protein
Phosphatidylethanolamine N-methyltransferase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Similarity
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
Sequence
MSSSAADPFAARLNSDVRQRHPTASATSKNVEGTSQQKQQQQQQQSEANAAASRVKKTYGKTPDGTVFVVPTTHDMVTQLLDPREPKNLSDVAVLAIIALHFLAAYYLPWGVKRPLFAAIFMFWRLAYNVGIGYLLTIQSKYKLLVTWAKRWKLFENPATGKNPRPWLYNLLKKELETKIPQDYKFEEAPIEYNTWLTFRRVVDLILMCDFISYCLFAIVCAHKPDGEGLFMCFARWAAGITLVGFNLWVKLDAHRVVKDYAWYWGDFFYLIEQELTFDGVFELAPHPMYSIGYAGYYGISMMAASYDVLFISIIAHAAQFAFLVIVENPHIEKTYNPPQPRVRCESEAGSQLQEFASEYSVPSTTGRHDNTPLPVHNLIGLKNLDFFRITDVAIVLLCAYLAVVTMVTPNTRFYQALFVLHALAWRLWYSAGLGVILTMQSEEKMFTRHFLKYGESVGEAWRQWKGIYHLSNCLCHASFIAASYKMYEFPADWTYGWALLKHVVGLSLIALQVWTATSIYESLGEFGWFYGDFFFDSKRQLTYTSIYRFLNNPERVFGTAGLWGAALITWSRAIFLMALAGHFLTLAFLAYVEKPHMQKVYGRNLRDDAGVTKFIKRSLPPPVTEWQQSIDKVLDETKHFIDEFVDAARSRLATGSSTIVKDTSALFNKYPARLTLSKISPDLAGYDPKHYGLSLAGTRVVGTNEKATGKESPNARVLKDVKTQAFEYGAPIRVKWTAPANHSKKDWVGLYMVTDNRSREVTEVPSLGRWVPTNPGEYDTTTDQGILVWDQPVEKKSEDTDLVEGEMVFEGDKLWWTQGVFEFRYHHGGGHHVMSISEPFEIQIPKFDDEHMGVDISGEVGERAVEAALLPVIRNCLDRDPDIAPSNAEERFGGHVERDGKYARRVVYAIRHMFGIDFAPAVVLADGNVRRLAWRICHAKEVLAPFSMSHTNGRTTPVDSKFSE