chk-1

Serine/threonine-protein kinase chk-1

503 amino acids

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:15326393). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:15326393). Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells (PubMed:15326393, PubMed:27956467). Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae (PubMed:26073019). Essential for embryogenesis (PubMed:15326393).

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

56.935 kDa

MSAASTTSTPAAAAVAPQQPESLYRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADPWYQHNFGQVETPNGRPLKRARNNDENITCTQQAECSAKRRHLETPNEKSTLAERQNASFSQPTKTEDLLLTQHIDMSQTNSNLLQRMVCRMTRFCVVTDIRSTYQKVARASEHAGFGVRETDDYRLLVTWREVSMMVSLYTMGDIPDKPRVMVDFRRSRGDGIQFKKMFMDVRNRMHEWICTDGNNWLANLGYVPRNPQIVNGGGVNVEHSASSINVDV

chk-1

Serine/threonine-protein kinase chk-1

493 amino acids

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Essential for embryogenesis (By similarity).

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

56.402 kDa

MSADVSTKPRGSLPIPTAPGESNECYRVIRTLGEGAFGEVLLIVNNKNPDMAVAMKKMQITTQANTNNIRKEFLIQQKLSKVGHDNFIRAIGMRTENGFHFLFLEYADGGELFDKIEPDHGMPTAIAQFYFRQLIEGLKYIHDCDIVHRDIKPENLLLTTSHVLKISDFGMATLYRNEGKERLLDLSCGTIPYAAPEVCAGGKYRGPPIDVWSSGIVLIAMLTGELPWDRASDSSYAYLQWLGNNNLDENPWRKMDVRALCMLRRILTDNVHRRATIEQIKTDPWFTHNYGKLEMTYGRPLKRARYADENSPDCNISSTQQADAVSTAKRRHLETPDKVAHVERQNASFSQPTRTEDLLLTQNIDMSQNNTNLLERMVCRMTRFCTKFDVPTSYRQLIHASEHAGYEVRQTADNRLLVTFREVSMMVTLYSLKTESRVMVDFRRSRGDGIQFKKMFLEVRNRMNDSICVDGQNFLEDCGYVPRKPQFVREANA