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chinmo

Gene
chinmo
Protein
Zinc finger protein chinmo
Organism
Drosophila melanogaster
Length
604 amino acids
Function
Required for morphological differentiation of postmitotic neurons during postembryonic brain development (PubMed:17055440). Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage (PubMed:17055440). Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye-antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis (PubMed:20412771). In the adult testis, maintains the male identify of adult somatic cyst stem cells by promoting expression of the male-specific isoform of transcription factor dsx which in turn regulates its own set of target genes that are critical for male sex identity (PubMed:25453558). Plays a role in actin nuclear localization through its involvement in repressing the expression of the kinase Cdi (PubMed:26021350). This maintains the cofilin/actin-depolymerizing factor homolog tsr in its unphosphorylated state which is required for actin nuclear import (PubMed:26021350).
Mass
62.23 kDa
Sequence
MDPQQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMGDLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGGGMAAAANAAASSLSTLAASANIVDRCGSAGANIISGSAAGIGGSHSGGAGNGSGTVGIGGNGVGSGGGNNGPISLGSGAGAAHHLGGSTGILKQECDSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPRKRAIVRSPYSEQEQRGSVLRDGSKSSECPSPINKPPYHRPSSSASSTAPTEADTMHSERASPQSSRYENHSPSTTAGNGNATSSLERIVKSERNNGSANEANDDDRELMDESTDNGAEDLRVKLENLKYSPPPPPNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQEIGLAAGATIAPAHLAAAAAASAAATAAASNHSP