Function
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (PubMed:24094853). Required for cilia integrity and function in sensory neurons (PubMed:2428682, PubMed:17314406, PubMed:24094853). Maintains cilia integrity, partly by modulating the assembly and transport of intraflagellar proteins along the ciliary axoneme (PubMed:24094853). Required for normal mating behavior and normal responses to environmental and chemical stimuli (PubMed:2428682, PubMed:17314406, PubMed:24094853).
Sequence
MKSAASSEDVVRVTEDLSECRNRLDAGIEENRRNRQVIQDINDQLQRFRQRANAESIESFNLTPSPDVTLSSLAHPGLTHLHNQTNISMPSLTIDIPLNSNAMISSSRTPNYAINGLRNRHKSLVGHRYRSTSPIGDYGRHRSSPRVLAHYNLDGADIGVGEENLDELFAKLKEELFKNNTLEEVNEMLREENDAALAANEHLRVDATNLSRQLQQLQQQQHTESMRFRSENTRYRNQTETQHRKLISLWKEFTAVKRQLHELRTTTANDLDRQLTEFTRCATLMRKAIRHAEQKNLDQKEQMKREKDDVLDETLRQLNSVTENYMKSEEKANERQRDLKRKEDECRKLREQNDELSDILEQLSKMAHEMAGGRGRNETPMDVARKMRKLLTTKNGEIDESREAAKQAEKERDRAKKDLEKEEKRRKDDREAERKRSSVYSQREHDLKKLDDELRKASEKIRNLEEQRESQEKLTISVQNSLNEAHRQHKQFIEELMIRHREELKEREDSHEEALRSKDTEERSRFEKERSEREKIRRESDELRETQRSLKGDVAAMKTDLDDKTLRLDMLETERDELKKKLETEREQADQRDLEIAECRAKLDEMAEKEAELRKELAEFQAIITAMEGEGKLNQEQFLESKNELNTLTDQIESLNSEVENKNEEIRNLMATLQEKEVHIQNVRTSSHQLTATYEEANGEIDILKAELTRLHEQVNERTRQISEANEKYDDAARKNDALLEDVATWQEKYEQLKMELEEMNRRGQEKEREEADLRALLDDLRGNFDKLTNELKQKGVTVDSLNEEISSLKEQLNKSEKERKEELLRMEELEQKNEAEMKEEYEVKLQLAEKDRQGVENFGKECEARMNELTKIHEMLMEEHDQLKVDHLHTEEEVERLKEKMRKELEKLNEQNDGDRAEWSNERNRLESSKNEAVTELQERVQKLEDVVKEKEDKEIALRRDLEDSHEKSRDLDDKLRKMELTDEEKEEDRKKEQKTLNEERMKLMEQKEEAMLVATKHATTIDQQTRRISVLEGDVEKLTAGIAERESSINALESNTMELISKLETTEAELEKLKDELAVMLKQNSELKNGKEGLSEKWNEERKKIQDLADQLREANKVVHNMRMKNVNLEEKKNELDQNVTDLTNKVRQLEIQLMDKAAKNEVSGDLLRKMEHDAQSMLKQAQNEQFRLTDLEKVRKALQDENQRLVNDLATVKAAFEVKRETSKSAISDILDKYRSAEEKANKGELDNQRLRSDLATVTLKLERQELKAKDSDNRLRDSQKRFEEVQSKLANLQKSAVESLQNPMSSNSRQNRSIYVDIPRAASSIGLNENSDEVPLRSSPSVRFADSSQNMQRAVDSMDVSSSVGVTLRFLKERIEQLEADNADLSDALEKAKDELRQRNEKLADRQMVIERVERQLVHITEERNTIENRMTSQRQMYLTNEESSRSREHEIRSMKARISTLELHLREKESKLAHLRKEIEVLHGQLHDALESKEKATGLVGVQDSKHRDLEEQLDRANRERELAIGKQRRTLAENENLFRKLEQLEKEREQLMREITDERRLNERNRTSLEELRVSERTWKSAMTTAKKPAEEQERAVQEQRRWEESNHEMTNRNTALTKECDRLRVEMRDQLNRMNGINLRSVDFERKNEELSSKLIVMQNTVTAMKKFEEEWKRLEAEMRAELKILRKEKLMQTAEIEDLKRKSFRSDTEKKEIEGIRVRLEREISALKRHVDALEEEKGKTEKAVRETMNERRAIDKSLASMERENQQLYRNCAQLQAQIQNLERDAGNRSVTKLAKEHSLLEARIAALIEEKRQLQSMLDQKDANYSHKRKLLESQIQLLREQLEAERRKRTKGVVATGPTVSRRGVQHTSAFRHTIERHRSLSQSSERTILQERYLEYVYTGDRTPAIQMINTPPISPLSHSGSFNSDGREARIRRESDNGHLQH