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cfbC

Gene
cfbC
Protein
Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, component CfbC
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
265 amino acids
Function
Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.
Similarity
Belongs to the NifH/BchL/ChlL family.
Mass
28.61 kDa
Sequence
MKKQKIVAIYGKGGIGKSSTASNVAAACAEAGKKVMIIGCDPKSDSSITLLRGKRIPTILDLLREGVDVQEKDVVFEGYAGVKCVEAGGPEPGIGCAGRGIIVAIQKLKSISGDLLKEQDLIIYDVPGDIVCGGFVAPVRKGYVNEAYVLTSGEYMPLYAANNICKGLSKIGMPLSGVICNSRNASREEEIVRKFSEEIGSQLMAFIPKRQIVQDCEREGYSVMEKAPDSDIAEVYRQLGKSILTNEKKVMASHLSDERLREMTK

Gene
cfbC
Protein
Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, component CfbC
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
265 amino acids
Function
Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.
Similarity
Belongs to the NifH/BchL/ChlL family.
Mass
28.578 kDa
Sequence
MKNQKIIAIYGKGGIGKSSTASNVAAACAEAGKKVMIIGCDPKSDSSITLLRGRRIPTILDLLREGVDIKKEDVVFEGYAGVKCVEAGGPEPGIGCAGRGIIVAIQKLKSISGNLLKEQDLIIYDVPGDIVCGGFVAPVRKGFVNEAYVLTSGEYMPLYAANNICKGLSKIGMPLSGVICNSRNVSREEEIVSKFSEEIGSQLMAFIPKRQVVQDCEREGYSVMEKAPESDIAEIYRKLGKAILENEKRVTADSLSDERLRELTK