CEP72

Centrosomal protein of 72 kDa

647 amino acids

Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).

Belongs to the CEP72 family.

71.718 kDa

MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISSLAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPHHPRAKCTEALAKQSLVMDADDEAVLNLIAECEWDLGRPPGSTSFSQKGREADSRGSQESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSYQELKKTMALFPHSSASHGGCQAC

Cep72

Centrosomal protein of 72 kDa

646 amino acids

Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity).

Belongs to the CEP72 family.

72.433 kDa

MAPGQRLVLCEETVRERSGLGPHRDLAELRSLSIPGTYQEKITHLGNSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVKNESDYRLFVVHMLPKLRQLDDRPVRESERKASQLHFAPEDSLNSKENFSTTLTVGRPHHLRNRCTETSAKKCLVMDADDEAVLNLIAECEWDLSNPPGNMSSSQKEHEADLHYAQESRHLLSPLSIQHQCGDSARRGHEKKKVTSRGCPGHSPQDQLCGELPLQHGLPEACHMHVQHARITSQPDSVDVEDCASSAQKSSLSSQKTVNPLPVPEKYRKRRMPGGRFQVPSDRECLSFLERADGPSSLEDSLSRQDGLEGQSQVALSHSEALEAEERTSHGTSDPRVLSPKLCSAAVPERRSTLEVALLEALLDLIDRCSSGSGSLHGNEAFLAQAKHVLSSLQEFTATRDSSALEKEGIGYLSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTSTALTLQITGLQASMKQLSGEVVELKQHVEHYDKIQELTQMLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFKKTTALIPHRSSRRGGRQSC

cep72

Centrosomal protein of 72 kDa

532 amino acids

Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Involved in centriole duplication (By similarity).

Belongs to the CEP72 family.

61.297 kDa

MAVDGLPITEQWIREKLNLQHRCLADVRSLTLPGTYEGKICHLGTSLKNFVRLKSLDLSYNALVTVQGIEHLELLERLNLYYNRLASLQDIFSLHKLQNLKELDLRLNPVVKKHPHYRLYLVHAIPKLRRLDDCPVRDRERKAALMHFSSEENLDSDYKKQVFIQDTTARSSDLRIKAMQKMVKTLSLLEGNEELALNDSSRKTGKRRSLQTLSVRCENECSPLLAHENPSESDIVYLFNDSDCRRSSKHKQESAPSKSSDYKNDARAGPHRVRFVSPVILRHSSVRGESVFTAHPDSHKQPHSHENDCSSPKWQNQLLDRANLVLHPPRLTYSTAETKDRSTKTLKGTYRKPMELLLSMMEDLWSEKKENQQNRTFLMKMVQILSMMEQEVSGGEQEIQTLKAALKASIAQADVQEKQHQSEIEELTLQQQQAHESIKRLNEQTKSLLEENVSLQKQLIRAEHKLLASRLKNIPHTQDRGVQSVPEEFNTKRDIIADDEDGGVGEQQQSYRSLIARNERLLQQLEEALMSK