Protein
mRNA-capping enzyme
Organism
Caenorhabditis elegans
Function
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
Similarity
In the C-terminal section; belongs to the eukaryotic GTase family.
Sequence
MATRGPTPDKARMGLPDRWLHCPKTGTLINNLFFPFKTPLCKMYDNQIAERRYQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFARYDPTEDDKILAPEKPDWEREMSIGMSTQIDNGRPSTSQQIPATNGNNNQNGNQLSGGGDNSKLFMDGLIRGVKVCEDEGKKSMLQAKIKNLCKYNKQGFPGLQPVSLSRGNINLLEQESYMVSWKADGMRYIIYINDGDVYAFDRDNEVFEIENLDFVTKNGAPLMETLVDTEVIIDKVEINGAMCDQPRMLIYDIMRFNSVNVMKEPFYKRFEIIKTEIIDMRTAAFKTGRLKHENQIMSVRRKDFYDLEATAKLFGPKFVQHVGHEIDGLIFQPKKTKYETGRCDKVLKWKPPSHNSVDFLLKVEKKCKEGMLPEWIGYLFVQNLSDPFGTMKATATLKKYHNKIIECTLLVDNQGRPKEWKFMRERTDKSLPNGLRTAENVVETMVNPVTETYLIEYVNHALRVLKRAAAAHRHHQIHQQQLHEGEPEARRQKL